发明申请
- 专利标题： Method of treatment using humanized anti-CD11a antibodies
- 专利标题（中）： 使用人源化抗CD11a抗体的治疗方法
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申请号： US10665658申请日： 2003-09-19
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公开(公告)号： US20050276801A1公开(公告)日： 2005-12-15
- 发明人: Paula Jardieu , Leonard Presta
- 申请人： Paula Jardieu , Leonard Presta
- 申请人地址： US CA South San Francisco 94080
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco 94080
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28 ; C12P21/08
摘要：
Humanized anti-CD11a antibodies and various uses therefor are disclosed. The humanized anti-CD11a antibody may bind specifically to human CD11a I-domain, have an IC50(nM) value of no more than about 1 nM for preventing adhesion of Jurkat cells to normal human epidermal keratinocytes expressing ICAM-1, and/or an IC50 (nM) value of no more than about 1 nM in the mixed lymphocyte response assay.
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