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    Compositions and methods for producing inhibitors of vascular endothelial growth factor activity
    2.
    发明授权
    Compositions and methods for producing inhibitors of vascular endothelial growth factor activity 有权
    用于产生血管内皮生长因子活性抑制剂的组合物和方法

    公开(公告)号：US08268591B2

    公开(公告)日：2012-09-18

    申请号：US13096734

    申请日：2011-04-28

    Applicant: Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    Inventor： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    IPC: C12N15/62 ,  C12N15/63 ,  C07H21/00

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K16/2863 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31

    Abstract: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

    Abstract translation: 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。

    Methods for using inhibitors of vascular endothelial growth factor activity
    3.
    发明授权
    Methods for using inhibitors of vascular endothelial growth factor activity 有权
    使用血管内皮生长因子活性抑制剂的方法

    公开(公告)号：US08268313B2

    公开(公告)日：2012-09-18

    申请号：US13096742

    申请日：2011-04-28

    Applicant: Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    Inventor： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    IPC: A61K38/18 ,  C07K14/71

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K16/2863 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31

    Abstract: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

    Abstract translation: 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。

    NOVEL INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY, THEIR USES AND PROCESSES FOR THEIR PRODUCTION
    4.
    发明申请
    NOVEL INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY, THEIR USES AND PROCESSES FOR THEIR PRODUCTION 审中-公开
    血管内皮生长因子活性的新型抑制剂，其生产用途及其制备方法

    公开(公告)号：US20110301338A1

    公开(公告)日：2011-12-08

    申请号：US13096753

    申请日：2011-04-28

    Applicant: Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    Inventor： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    IPC: C07K16/22

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K16/2863 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31

    Abstract: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

    Abstract translation: 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。

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