发明申请
US20050287620A1 METHOD OF DETERMINING ANALYTE LEVEL USING SUBCUTANEOUS ELECTRODE
审中-公开
使用细胞电极测定分析物水平的方法
- 专利标题: METHOD OF DETERMINING ANALYTE LEVEL USING SUBCUTANEOUS ELECTRODE
- 专利标题(中): 使用细胞电极测定分析物水平的方法
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申请号: US11109379申请日: 2005-04-19
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公开(公告)号: US20050287620A1公开(公告)日: 2005-12-29
- 发明人: Adam Heller , Michael Pishko
- 申请人: Adam Heller , Michael Pishko
- 申请人地址: US CA Alameda
- 专利权人: TheraSense, Inc.
- 当前专利权人: TheraSense, Inc.
- 当前专利权人地址: US CA Alameda
- 主分类号: G01N27/327
- IPC分类号: G01N27/327 ; A61B5/145 ; A61B5/1473 ; A61B5/1486 ; A61B5/1495 ; C12M1/40 ; C12Q1/00 ; C12Q1/54
摘要:
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.