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公开(公告)号：US20240293788A1
公开(公告)日：2024-09-05
申请号：US18565297
申请日：2022-06-09
摘要： The present invention relates to devices for maintaining a state of equilibrium, and process set-ups to perform equilibrium reactions using heterogeneous catalysts, in particular said reactions are equilibrium reactions where at least one reaction product is volatile. The invention is especially interesting for enzymatic reactions using immobilized enzymes, although it is also useful for pure chemical reactions. The invention is characterized by a combination of non-impact mixing of components and volatilization and/or removal of excess molecules, thereby maintaining a state of equilibrium or driving an equilibrium reaction. The present invention also relates to devices and/or process set-ups and materials made using said processes.
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2.发明公开公开(公告)号：US20230265374A1
公开(公告)日：2023-08-24
申请号：US17960099
申请日：2022-10-04
发明人： SALEHA AL-MARDEAI , SULAIMAN AL-ZUHAIR , BART VAN DER BRUGGEN , EMAD ELNAJJAR , BOGUSLAW KRUKZEK
CPC分类号： C12M21/18 , C12P7/10 , C13K1/04 , C12M29/04 , C12N9/2437
摘要： The membrane bioreactor for simultaneous enzymatic cellulose hydrolysis and product separation is a vessel having a lower hydrolysis reaction chamber and an upper distilled water chamber separated by a semipermeable membrane attached to the top of the lower reaction chamber. The membrane is supported on a stainless steel mesh and sealed to the mesh by epoxy glue to prevent leakage. A peristaltic pump is connected to the reaction chamber and maintains a flow of distilled water through the membrane and the upper chamber, the effluent being collected in a beaker or other product collection vessel. The reaction chamber is agitated at a moderate rate by a magnetic stirrer, and the upper chamber is agitated more rigorously by a mechanical stirrer. A thermocouple and temperature controller and a buffer solution, respectively, maintain temperature and pH in the reaction chamber optimal for enzymatic hydrolysis of cellulose.
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公开(公告)号：US20230167477A1
公开(公告)日：2023-06-01
申请号：US17982080
申请日：2022-11-07
CPC分类号： C12P21/00 , B01L3/502761 , C12M21/18 , C12M41/32 , C12M47/10 , B01L2400/043 , B01L2400/0427 , B01L2200/04 , B01L2200/0652 , B01L2200/16
摘要： The invention provided herein relates to methods for protein synthesis, characterisation and purification on a digital microfluidic device.
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公开(公告)号：US20230151317A1
公开(公告)日：2023-05-18
申请号：US17913392
申请日：2021-04-16
CPC分类号： C12M21/18 , C12P19/34 , C12N9/1241 , C12M33/14 , C12M47/12
摘要： The invention includes novel, systems, methods and compositions for the in vitro production of polynucleotides, and in particular the production of mRNA for use in therapeutic applications.
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公开(公告)号：US20230080444A1
公开(公告)日：2023-03-16
申请号：US17946862
申请日：2022-09-16
发明人： Kenneth T. Kotz , Bryan D. Teece , James Gillett Truslow , Nathan Francis Moore , Jeffrey T. Borenstein , Vishal Tandon
摘要： A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
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公开(公告)号：US20230074987A1
公开(公告)日：2023-03-09
申请号：US17903404
申请日：2022-09-06
IPC分类号： C12M1/00 , B01D53/78 , B01D53/18 , C01F5/24 , C01F11/18 , C04B22/10 , C04B28/04 , C01B32/60 , B01D53/62 , C12M1/40
摘要： Aspects of the invention include methods of removing carbon dioxide (CO2) from a CO2 containing gas. In some instances, the methods include contacting CO2 containing gas with a bicarbonate buffered aqueous medium under conditions sufficient to produce a bicarbonate rich product. Where desired, the resultant bicarbonate rich product or a component thereof may then be stored or further processed, e.g., combined with a divalent alkaline earth metal cation, under conditions sufficient to produce a solid carbonate composition. Aspects of the invention further include systems for practicing the methods, as well as products produced by the methods.
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公开(公告)号：US20230054615A1
公开(公告)日：2023-02-23
申请号：US17903432
申请日：2022-09-06
IPC分类号： C12M1/00 , B01D53/78 , B01D53/18 , C01F5/24 , C01F11/18 , C04B22/10 , C04B28/04 , C01B32/60 , B01D53/62 , C12M1/40
摘要： Aspects of the invention include methods of removing carbon dioxide (CO2) from a CO2 containing gas. In some instances, the methods include contacting CO2 containing gas with a bicarbonate buffered aqueous medium under conditions sufficient to produce a bicarbonate rich product. Where desired, the resultant bicarbonate rich product or a component thereof may then be stored or further processed, e.g., combined with a divalent alkaline earth metal cation, under conditions sufficient to produce a solid carbonate composition. Aspects of the invention further include systems for practicing the methods, as well as products produced by the methods.
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公开(公告)号：US11584908B2
公开(公告)日：2023-02-21
申请号：US16137478
申请日：2018-09-20
发明人： Kenneth T. Kotz , Bryan D. Teece , James Gillett Truslow , Nathan Francis Moore , Jeffrey T. Borenstein , Vishal Tandon
IPC分类号： C12M1/02 , C12M1/12 , C12N15/87 , C12M1/00 , C12N15/86 , C12M3/06 , C12M1/40 , C12M1/34 , A61K48/00
摘要： A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
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公开(公告)号：US11511213B2
公开(公告)日：2022-11-29
申请号：US15752121
申请日：2016-08-12
发明人： Jonathan L. Belanger , Hua Yang , Edouard S. P. Bouvier , Mathew DeLano , Raymond P. Fisk , Hillary B. Hewitson , Wade P. Leveille , Kevin Daniel Wyndham
摘要： Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.
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公开(公告)号：US11499143B2
公开(公告)日：2022-11-15
申请号：US15521104
申请日：2015-10-23
申请人： Kikkoman Corporation
IPC分类号： C12N9/06 , C12Q1/26 , C12Q1/00 , G01N27/416 , C12M1/40 , G01N27/327
摘要： Provided are an amadoriase that is less likely to be influenced by oxygen concentration and a method and a reagent kit for measurement of HbA1c using such amadoriase. Provided are an amadoriase that is obtained via substitution of one or more amino acid residues at a position or positions corresponding to the position(s) selected from the group consisting of positions 280, 267, 269, 54, and 241 of the amadoriase derived from the genus Coniochaeta, a method for measurement of HbA1c, a reagent kit for measurement, and a sensor using such amadoriase. The modified amadoriase according to the invention has a lowered oxidase activity and an enhanced dehydrogenase activity, and this enables the use of an electron mediator, and this reduces the influence of oxygen concentration. Thus, HbA1c can be measured with high sensitivity.
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