公开(公告)号：US20090048501A1

公开(公告)日：2009-02-19

申请号：US10891327

申请日：2004-07-14

申请人： Timothy T. Goodnow

发明人： Timothy T. Goodnow

IPC分类号： G06F19/00 ,  A61B5/1477

CPC分类号： A61B5/0022 ,  A61B5/0002 ,  A61B5/0024 ,  A61B5/14532 ,  A61B2560/0431 ,  A61B2560/0456 ,  A61B2560/06 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/63

摘要： A glucose meter module integrated into a holster device that can securely accommodate another device such as a portable server device or an insulin pump is described. The glucose measuring module and the health device communicate with each other by a short range wireless modality. In the case in which the accommodated device is a server, such as personal digital assistant or cell phone, the device stores data in a memory, displays data on a visual display, and can wirelessly transmit such data to other devices within a personal area network. In the case where the accommodated device is a cell phone, the phone can further transmit data to remote sites. In the case where the accommodated device is an insulin pump, wirelessly received data are stored in a memory, are available for visual display on the insulin pump, and can be incorporated into the electronic processes that regulate the performance of the pump.

摘要翻译： 描述集成到可以可靠地容纳诸如便携式服务器设备或胰岛素泵的另一设备的机架设备中的葡萄糖计模块。 葡萄糖测量模块和健康装置通过短距离无线模式相互通信。 在容纳设备是诸如个人数字助理或手机的服务器的情况下，设备将数据存储在存储器中，在可视显示器上显示数据，并且可以将这些数据无线地发送到个人区域网络内的其他设备 。 在被容纳的设备是手机的情况下，电话机可以进一步向远程站点发送数据。 在所容纳的装置是胰岛素泵的情况下，将无线接收的数据存储在存储器中，可用于胰岛素泵上的视觉显示，并且可以并入调节泵的性能的电子过程中。

公开(公告)号：US20080277294A1

公开(公告)日：2008-11-13

申请号：US12027825

申请日：2008-02-07

申请人： Adam Heller ,  Benjamin J. Feldman ,  James Say ,  Mark S. Vreeke

发明人： Adam Heller ,  Benjamin J. Feldman ,  James Say ,  Mark S. Vreeke

IPC分类号： G01N33/50

CPC分类号： G01N27/3272 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/157 ,  A61B2560/0223 ,  A61B2562/0295 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3273 ,  G01N33/5438 ,  G01N2333/904

摘要： A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable.The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used.The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.

公开(公告)号：US20080060955A1

公开(公告)日：2008-03-13

申请号：US11858669

申请日：2007-09-20

申请人： Timothy Goodnow

发明人： Timothy Goodnow

IPC分类号： B65D85/38

CPC分类号： A61B5/0022 ,  A61B5/0002 ,  A61B5/0024 ,  A61B5/14532 ,  A61B2560/0431 ,  A61B2560/0456 ,  A61B2560/06 ,  G06F19/3468 ,  G16H40/63

摘要： A glucose meter module integrated into a holster device that can securely accommodate another device such as a portable server device or an insulin pump is described. The glucose measuring module and the health device communicate with each other by a short range wireless modality. In the case in which the accommodated device is a server, such as personal digital assistant or cell phone, the device stores data in a memory, displays data on a visual display, and can wirelessly transmit such data to other devices within a personal area network. In the case where the accommodated device is a cell phone, the phone can further transmit data to remote sites. In the case where the accommodated device is an insulin pump, wirelessly received data are stored in a memory, are available for visual display on the insulin pump, and can be incorporated into the electronic processes that regulate the performance of the pump.

摘要翻译： 描述集成到可以可靠地容纳诸如便携式服务器设备或胰岛素泵的另一设备的机架设备中的葡萄糖计模块。 葡萄糖测量模块和健康装置通过短距离无线模式相互通信。 在容纳设备是诸如个人数字助理或手机的服务器的情况下，设备将数据存储在存储器中，在可视显示器上显示数据，并且可以将这些数据无线地发送到个人区域网络内的其他设备 。 在被容纳的设备是手机的情况下，电话机可以进一步向远程站点发送数据。 在所容纳的装置是胰岛素泵的情况下，将无线接收的数据存储在存储器中，可用于胰岛素泵上的视觉显示，并且可以并入调节泵的性能的电子过程中。

公开(公告)号：US20070027381A1

公开(公告)日：2007-02-01

申请号：US11192773

申请日：2005-07-29

申请人： Gary Stafford

发明人： Gary Stafford

IPC分类号： A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/14532 ,  A61B2560/063

摘要： Method and apparatus for providing a housing integrated with a sensor introducer and a sensor in analyte monitoring system to deploy the sensor and retain the introducer within the housing upon sensor deployment, and mounting a transmitter to the housing to receive the sensor data is described. The housing may be placed on the skin of a patient and a spring biased mechanism, separately provided and coupled to the introducer or by integrally configuring the introducer, triggers the introducer to deploy the insertion mechanism for placement of the sensor at a predetermined depth under the skin of the patient.

摘要翻译： 描述了一种用于提供与分析物监测系统中的传感器引导器和传感器集成的壳体的方法和装置，以在传感器部署时部署传感器并将引导器保持在壳体内，并且将发射器安装到壳体以接收传感器数据。 壳体可以放置在患者的皮肤上，并且单独设置并联接到导引器的弹簧偏压机构或通过整体地构造导引器来触发导引器来展开插入机构，以将传感器放置在预定深度的下方 病人皮肤。

公开(公告)号：US20060247508A1

公开(公告)日：2006-11-02

申请号：US11118794

申请日：2005-04-29

申请人： Martin Fennell

发明人： Martin Fennell

IPC分类号： A61B5/05

CPC分类号： G01R31/025 ,  A61B5/0008 ,  A61B5/14532 ,  A61B5/4839 ,  G01R31/2829

摘要： Method and apparatus for providing a leak detection circuit for data monitoring and management system using the guard trace of a glucose sensor by applying a leak detection test signal to determine whether a leakage current is present is provided. The leak detection circuit may includes an interface circuit such as a capacitor coupled to the guard trace to detect the leakage current when the leak detection test signal is applied to the guard trace, such that the user or patient using the data monitoring and management system such as glucose monitoring systems may be promptly and accurately notified of a failed sensor, and to alert the user to replace the sensor.

摘要翻译： 提供了一种通过应用泄漏检测测试信号来确定是否存在泄漏电流来提供使用葡萄糖传感器的保护迹线的数据监视和管理系统的泄漏检测电路的方法和装置。 泄漏检测电路可以包括接口电路，例如耦合到保护迹线的电容器，以便当泄漏检测测试信号被施加到保护迹线时检测泄漏电流，使得使用数据监视和管理系统的用户或患者 因为葡萄糖监测系统可以及时且准确地通知故障传感器，并且提醒用户更换传感器。

公开(公告)号：US07058437B2

公开(公告)日：2006-06-06

申请号：US10418396

申请日：2003-04-17

申请人： John Bernard Buse ,  Alan Charles Moses

发明人： John Bernard Buse ,  Alan Charles Moses

IPC分类号： A61B5/05

CPC分类号： A61B5/150412 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/15144 ,  A61B5/15194 ,  A61B2562/0295 ,  C12Q1/006 ,  G01N27/3272 ,  G01N33/48707 ,  G01N33/49 ,  G01N33/66

摘要： A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.

摘要翻译： 除了指尖之外，刺激皮肤区域。 在刺激之后，在皮肤中产生开口（例如，通过穿刺皮肤）引起来自该区域的体液流动。 将该体液的至少一部分输送到测定装置，在该测试装置中，然后确定体液中分析物（例如葡萄糖）的浓度。 发现皮肤的刺激提供的结果通常更接近于来自指尖的测量结果，传统的用于获得用于分析物测试的体液的部位。

公开(公告)号：US20050278945A1

公开(公告)日：2005-12-22

申请号：US10661437

申请日：2003-09-12

申请人： Benjamin Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph Vivolo ,  Jeffery Funderburk ,  Fredric Colman ,  Rajesh Krishnan

发明人： Benjamin Feldman ,  Adam Heller ,  Ephraim Heller ,  Fei Mao ,  Joseph Vivolo ,  Jeffery Funderburk ,  Fredric Colman ,  Rajesh Krishnan

IPC分类号： G01N33/483 ,  C12Q1/00 ,  C12Q1/26 ,  G01N27/327 ,  G01N27/416 ,  G01N27/42 ,  G01N33/66 ,  H05K3/36 ,  A61B5/05

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

公开(公告)号：US06942518B2

公开(公告)日：2005-09-13

申请号：US10033506

申请日：2001-12-28

申请人： Charles T. Liamos ,  Benjamin J. Feldman ,  Jeffery V. Funderburk ,  Rajesh Krishnan ,  Phillip John Plante ,  Joseph A. Vivolo ,  Robert Y. Jin ,  Michael S. Cloud

发明人： Charles T. Liamos ,  Benjamin J. Feldman ,  Jeffery V. Funderburk ,  Rajesh Krishnan ,  Phillip John Plante ,  Joseph A. Vivolo ,  Robert Y. Jin ,  Michael S. Cloud

IPC分类号： A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  G01N27/22 ,  G01N27/28 ,  G01N27/327 ,  G01N27/403 ,  G01N27/416 ,  G01N27/42 ,  G01N33/487 ,  H01R9/07

CPC分类号： G01N27/3272 ,  Y10S439/909

摘要： A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the analyte using the amount of charge and the amount of time.

摘要翻译： 使用诸如库仑法，电流分析法和电位法的生物流体（例如血液或血清）来确定分析物如葡萄糖或乳酸盐的浓度的小体积传感器和制备方法。 传感器包括工作电极和对电极，并且可以包括插入监视轨迹，以确定传感器在连接器中的正确定位。 在一个实施例中，传感器通过将一定量的电荷排出到样品中来确定分析物的浓度，确定放电所需的时间，以及使用电荷量确定用于电解一部分分析物的电流， 多少时间。

公开(公告)号：US20040186365A1

公开(公告)日：2004-09-23

申请号：US10745878

申请日：2003-12-26

申请人： TheraSense, Inc.

发明人： Robert Y. Jin ,  Mark K. Sloan

IPC分类号： A61B005/00

CPC分类号： A61B5/01 ,  A61B5/0002 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00

摘要： A continuous glucose monitoring system including a sensor configured to detect one or more glucose levels, a transmitter operatively coupled to the sensor, the transmitter configured to receive the detected one or more glucose levels, the transmitter further configured to transmit signals corresponding to the detected one or more glucose levels, and a receiver operatively coupled to the transmitter configured to receive transmitted signals corresponding to the detected one or more glucose levels, and methods thereof, are disclosed. In one aspect, the transmitter may be configured to transmit a current data point and at least one previous data point, the current data point and the at least one previous data point corresponding to the detected one or more glucose levels.

摘要翻译： 一种连续的葡萄糖监测系统，包括被配置为检测一个或多个葡萄糖水平的传感器，可操作地耦合到所述传感器的发射器，被配置为接收所检测的一个或多个葡萄糖水平的所述发射器，所述发射器还被配置为发射与所检测到的一个 或更多的葡萄糖水平，以及可操作地耦合到发射机的接收机，其被配置为接收与所检测到的一个或多个葡萄糖水平相对应的发射信号及其方法。 在一个方面，发射机可以被配置为发送当前数据点和至少一个先前数据点，当前数据点和对应于检测到的一个或多个葡萄糖水平的至少一个先前数据点。

公开(公告)号：US20040106858A1

公开(公告)日：2004-06-03

申请号：US10722246

申请日：2003-11-24

申请人： TheraSense, Inc.

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B005/00

CPC分类号： A61B5/14532 ,  A61B5/0002 ,  A61B5/14546 ,  A61B5/7445 ,  G06Q50/22 ,  H01L23/3107 ,  H01L23/49548 ,  H01L24/48 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2924/00014 ,  H01L2924/01012 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y02A90/22 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.