发明申请
US20050287625A1 Process for expression of foreign genes in methylotrophic bacteria through chromosomal integration
审中-公开
通过染色体整合在甲基营养细菌中表达外源基因的方法
- 专利标题： Process for expression of foreign genes in methylotrophic bacteria through chromosomal integration
- 专利标题（中）： 通过染色体整合在甲基营养细菌中表达外源基因的方法
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申请号： US11070080申请日： 2005-03-02
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公开(公告)号： US20050287625A1公开(公告)日： 2005-12-29
- 发明人: Edward Miller , Rick Ye
- 申请人： Edward Miller , Rick Ye
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; C12N1/21 ; C12N9/00 ; C12N15/74 ; C12P21/00 ; C12P23/00 ; C12R1/26
摘要：
Provided is a method for expressing an introduced gene or genes in a C1 metabolizing microorganism host wherein the gene(s) are integrated into the tig region of the chromosome. This method provides high level expression in a stable manner in which growth rate of the host strain is not highly affected and a selection marker is not required. The use of this method for expressing carotenoid biosynthetic genes and resulting production of canthaxanthin is also described.
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