发明申请
- 专利标题： Methods for the synthesis of substituted purines
- 专利标题（中）： 合成取代嘌呤的方法
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申请号： US11223429申请日： 2005-09-09
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公开(公告)号： US20060009642A1公开(公告)日： 2006-01-12
- 发明人: Sheng Ding , Qiang Ding , Nathanael Gray , Peter Schultz
- 申请人： Sheng Ding , Qiang Ding , Nathanael Gray , Peter Schultz
- 申请人地址： BM Hamilton HM LX
- 专利权人： IRM LLC, a Delaware Limited Liability Company
- 当前专利权人： IRM LLC, a Delaware Limited Liability Company
- 当前专利权人地址： BM Hamilton HM LX
- 主分类号： C07D473/24
- IPC分类号： C07D473/24 ; C07D473/16
摘要：
The invention provides general methods for preparing 2,9-, 2,6,9-, O6-aryl- and O6-alkyl-substituted purines in a combinatorial and traceless fashion. The methods involve, in some embodiments, Mitsunobu alkylation of 2-fluoro-6-phenylsulfenylpurine at N9 with alcohols in solution, followed by C2-capture of the purine core with a resin-bound amine and subsequent oxidation and displacement of the C6 sulfonyl group with amines and anilines.