发明申请
US20060014814A1 Derivatives of 1,2-benzisoxazole-3-methane sulfonic acid as novel intermediates for the synthesis of zonisamide
失效
1,2-苯并异恶唑-3-甲磺酸的衍生物作为合成唑尼沙胺的新中间体
- 专利标题： Derivatives of 1,2-benzisoxazole-3-methane sulfonic acid as novel intermediates for the synthesis of zonisamide
- 专利标题（中）： 1,2-苯并异恶唑-3-甲磺酸的衍生物作为合成唑尼沙胺的新中间体
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申请号： US11153402申请日： 2005-06-16
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公开(公告)号： US20060014814A1公开(公告)日： 2006-01-19
- 发明人: Vladimir Naddaka , Eyal Klopfer , Shady Saeed , Oded Arad , Joseph Kaspi
- 申请人： Vladimir Naddaka , Eyal Klopfer , Shady Saeed , Oded Arad , Joseph Kaspi
- 主分类号： C07D261/20
- IPC分类号： C07D261/20 ; A61K31/42
摘要：
Derivatives of 1,2-benzisoxazole-3-methanesulfonic acid, which are non-hygroscopic and non-hydrated and their use as intermediates fro the preparation of zonisamide are disclosed. Further disclosed are processes of preparing zonisamide from these 1,2-benzisoxazole-3-methanesulfonic acid derivatives, processes of preparing exemplary 1,2-benzisoxazole-3-methanesulfonic acid derivatives and crystalline forms of exemplary 2-benzisoxazole-3-methanesulfonic acid derivatives. A novel process of preparing zonisamide is also disclosed.
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