发明申请
US20060030543A1 Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease
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多环磺酰胺化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病
- 专利标题: Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease
- 专利标题(中): 多环磺酰胺化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病
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申请号: US11150500申请日: 2005-06-09
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公开(公告)号: US20060030543A1公开(公告)日: 2006-02-09
- 发明人: James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
- 申请人: James Malecha , Stewart Noble , Christian Hassig , Paul Wash , Brandon Wiley , Charles Lawrence , Timothy Hoffman
- 优先权: WOPCT/US04/18502 20040610
- 主分类号: A61K31/675
- IPC分类号: A61K31/675 ; A61K31/55 ; A61K31/519 ; A61K31/4745 ; A61K31/4743 ; A61K31/47 ; A61K31/404
摘要:
Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.