- 专利标题: Human antibodies derived from immunized xenomice
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申请号: US10656623申请日: 2003-09-04
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公开(公告)号: US20060040363A1公开(公告)日: 2006-02-23
- 发明人: Raju Kucherlapati , Aya Jakobovits , Sue Klapholz , Daniel Brenner , Daniel Capon
- 申请人: Raju Kucherlapati , Aya Jakobovits , Sue Klapholz , Daniel Brenner , Daniel Capon
- 主分类号: C12P21/04
- IPC分类号: C12P21/04 ; C12N5/06
摘要:
Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.