发明申请
US20060052608A1 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
失效
4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途
- 专利标题： 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
- 专利标题（中）： 4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途
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申请号： US11249543申请日： 2005-10-12
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公开(公告)号： US20060052608A1公开(公告)日： 2006-03-09
- 发明人: Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
- 申请人： Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
- 专利权人： WARNER-LAMBERT COMPANY LLC
- 当前专利权人： WARNER-LAMBERT COMPANY LLC
- 主分类号： C07D221/02
- IPC分类号： C07D221/02 ; C07C259/04
摘要：
Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
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