Invention Application
US20060052608A1 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
失效
4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途
- Patent Title: 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
- Patent Title (中): 4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途
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Application No.: US11249543Application Date: 2005-10-12
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Publication No.: US20060052608A1Publication Date: 2006-03-09
- Inventor: Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
- Applicant: Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
- Assignee: WARNER-LAMBERT COMPANY LLC
- Current Assignee: WARNER-LAMBERT COMPANY LLC
- Main IPC: C07D221/02
- IPC: C07D221/02 ; C07C259/04
Abstract:
Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
Public/Granted literature
- US07169816B2 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Public/Granted day:2007-01-30
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