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1.发明申请4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors 审中-公开4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途公开(公告)号：US20050049429A1
公开(公告)日：2005-03-03
申请号：US10967427
申请日：2004-10-18
Applicant: Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
Inventor： Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
IPC: C07C259/10 , C07D211/22 , C07D295/088 , C07D307/42 , C07D309/06 , C07D333/16 , C07C239/22
CPC classification number: C07D295/088 , C07C259/10 , C07D211/22 , C07D213/30 , C07D307/42 , C07D309/06 , C07D333/16
Abstract: Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
Abstract translation: 下式的苯基氨基苯并肟酸衍生物其中R 1，R 2，R 3，R 4，R 5和R 6是氢或取代基如烷基，并且其中R 7是氢或有机基团是MEK的有效抑制剂，因此是 有效治疗癌症和其他增殖性疾病如牛皮癣和再狭窄。
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2.发明授权公开(公告)号：US06544983B2
公开(公告)日：2003-04-08
申请号：US09876719
申请日：2001-06-07
Applicant: Annette Doherty
Inventor： Annette Doherty
IPC: A61K3155
CPC classification number: A61K31/5517
Abstract: The present invention relates to the use of diazepinoindoles of the formula (I): in which A is aryl or nitrogen-containing heteroaryl, and B is a hydroxyl or amino radical, for the treatment of chronic obstructive pulmonary disease.
Abstract translation: 本发明涉及式（I）的二氮杂吲哚的用途：其中A为芳基或含氮杂芳基，B为羟基或氨基，用于治疗慢性阻塞性肺疾病。
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3.发明申请4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors 失效4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途公开(公告)号：US20060052608A1
公开(公告)日：2006-03-09
申请号：US11249543
申请日：2005-10-12
Applicant: Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
Inventor： Stephen Barrett , Alexander Bridges , Annette Doherty , David Dudley , Alan Saltiel , Haile Tecle
IPC: C07D221/02 , C07C259/04
CPC classification number: C07D295/088 , C07C259/10 , C07D211/22 , C07D213/30 , C07D307/42 , C07D309/06 , C07D333/16
Abstract: Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
Abstract translation: 苯基氨基苯肟酸衍生物
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