- 专利标题: Novel HCV non-structural polypeptide
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申请号: US11195009申请日: 2005-08-02
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公开(公告)号: US20060057164A1公开(公告)日: 2006-03-16
- 发明人: Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
- 申请人: Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
- 申请人地址: US CA Emeryville
- 专利权人: Chiron Corporation
- 当前专利权人: Chiron Corporation
- 当前专利权人地址: US CA Emeryville
- 主分类号: C07K14/18
- IPC分类号: C07K14/18 ; C12Q1/70 ; C07H21/04 ; A61K39/29 ; C12N5/04 ; C12N1/18 ; C12N5/06
摘要:
Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.