Invention Application
US20060074092A1 Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine structure and cathepsin K inhibitory activity for the treatment of inflammations and other diseases
审中-公开
具有2-氰基-4-氨基 - 嘧啶结构的半胱氨酸蛋白酶抑制剂和用于治疗炎症等疾病的组织蛋白酶K抑制活性
- Patent Title: Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine structure and cathepsin K inhibitory activity for the treatment of inflammations and other diseases
- Patent Title (中): 具有2-氰基-4-氨基 - 嘧啶结构的半胱氨酸蛋白酶抑制剂和用于治疗炎症等疾病的组织蛋白酶K抑制活性
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Application No.: US11291007Application Date: 2005-11-30
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Publication No.: US20060074092A1Publication Date: 2006-04-06
- Inventor: Eva Altmann , Kenji Hayakawa , Genji Iwasaki
- Applicant: Eva Altmann , Kenji Hayakawa , Genji Iwasaki
- Priority: GB0121026.9 20010830; GB0121024.4 20010830
- Main IPC: C07D239/42
- IPC: C07D239/42 ; A61K31/505
Abstract:
The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof (I), wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g., various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors.
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