发明申请
US20060100140A1 Combination of a) n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]2-methylphenyl}-4- (3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia
审中-公开
a）正 - {5- [4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺的组合和b）组蛋白脱乙酰酶抑制剂 治疗白血病
![Combination of a) n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]2-methylphenyl}-4- (3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia](/docs/US/2006-05-11/US20060100140A1/abs.jpg.600x600.jpg)
- 专利标题： Combination of a) n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]2-methylphenyl}-4- (3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia
- 专利标题（中）： a）正 - {5- [4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺的组合和b）组蛋白脱乙酰酶抑制剂 治疗白血病
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申请号： US10527553申请日： 2003-09-10
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公开(公告)号： US20060100140A1公开(公告)日： 2006-05-11
- 发明人: Paul Dent , Steven Grant , Geoffrey Krystal , Chunrong Yu
- 申请人： Paul Dent , Steven Grant , Geoffrey Krystal , Chunrong Yu
- 国际申请： PCT/IB03/04053 WO 20030910
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K31/506 ; A61K31/405 ; A61K31/19
![Combination of a) n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]2-methylphenyl}-4- (3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia](/abs-image/US/2006/05/11/US20060100140A1/abs.jpg.150x150.jpg)
摘要：
The invention pertains to a combination of a histone deacetylase inhibitor and N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine or a pharmaceutically acceptable salt thereof for simultaneous, separate or sequential use for the treatment of leukemia and especially N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-resistant leukemia.
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