发明申请
US20060110375A1 Method for producing cell lines and organs by means of differentiable cells
审中-公开
通过可微细胞生产细胞系和器官的方法
- 专利标题: Method for producing cell lines and organs by means of differentiable cells
- 专利标题(中): 通过可微细胞生产细胞系和器官的方法
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申请号: US10524187申请日: 2003-08-11
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公开(公告)号: US20060110375A1公开(公告)日: 2006-05-25
- 发明人: Herbert Zech , Nicolas Zech , Gottfried Dohr , Pierre Vanderzwalmen
- 申请人: Herbert Zech , Nicolas Zech , Gottfried Dohr , Pierre Vanderzwalmen
- 优先权: ATA1206/2002 20020809
- 国际申请: PCT/AT03/00232 WO 20030811
- 主分类号: A61K48/00
- IPC分类号: A61K48/00 ; C12N5/06
摘要:
A method for producing cell lines or individual organs, differentiable donor cells being supplied to a morula or blastocyst which is cultivated under conditions that ensure a further development of the morula or blastocyst in stages in which newly formed cell lines having a higher degree of differentiation occur, as well as isolation of the cell lines or further differentiation of the cell lines into organs. The method according to the present invention is distinguished in that the cells of the morula or the internal cell mass of the blastocyst have a restricted survivability in comparison to the particular wild type or their survivability is reduced through suitable cultivation conditions, and the donor cells supplied to the morula or blastocyst have varying degrees of differentiation. A significantly shortened cultivation period of the donor cells may thus be achieved in comparison to typical methods, through which the provision of natural stem cells is favored, and perhaps made possible for the first time. The blastocysts may also be used by being transferred into a surrogate mother animal.
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