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1.发明申请公开(公告)号：US20060110375A1
公开(公告)日：2006-05-25
申请号：US10524187
申请日：2003-08-11
CPC分类号： G07D3/14 , C12N15/873
摘要： A method for producing cell lines or individual organs, differentiable donor cells being supplied to a morula or blastocyst which is cultivated under conditions that ensure a further development of the morula or blastocyst in stages in which newly formed cell lines having a higher degree of differentiation occur, as well as isolation of the cell lines or further differentiation of the cell lines into organs. The method according to the present invention is distinguished in that the cells of the morula or the internal cell mass of the blastocyst have a restricted survivability in comparison to the particular wild type or their survivability is reduced through suitable cultivation conditions, and the donor cells supplied to the morula or blastocyst have varying degrees of differentiation. A significantly shortened cultivation period of the donor cells may thus be achieved in comparison to typical methods, through which the provision of natural stem cells is favored, and perhaps made possible for the first time. The blastocysts may also be used by being transferred into a surrogate mother animal.
摘要翻译： 一种生产细胞系或单个器官的方法，将可分化的供体细胞供应到桑ula或胚泡，其在确保新生成的具有较高分化程度的细胞系的阶段中进一步发育桑ula或胚泡的条件下培养 ，以及细胞系的分离或细胞系进一步分化成器官。 根据本发明的方法的特征在于，与特定野生型相比，囊胚的细胞或囊胚的内部细胞团体具有限制的存活性，或者通过合适的培养条件降低它们的存活力，并且供体细胞 对桑ula或囊胚有不同程度的分化。 与典型的方法相比，可以实现供体细胞的显着缩短的培养期，通过这些方法天然干细胞的提供是有利的，并且可能是第一次可能的。 囊胚也可以通过转移到替代母亲动物中使用。
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公开(公告)号：US20080255034A1
公开(公告)日：2008-10-16
申请号：US12089445
申请日：2006-10-06
申请人： Christof Bohler , Thomas Bragagna , Reinhard Braun , Werner Braun , Herbert Zech
发明人： Christof Bohler , Thomas Bragagna , Reinhard Braun , Werner Braun , Herbert Zech
CPC分类号： A61N1/327 , A61B18/203 , A61B2017/00765 , A61B2018/00452 , A61K9/0021
摘要： The transdermal delivery system for treating infertility in a patient comprises an apparatus (10) for facilitating transdermal delivery of a drug (5a) through an area of the apparatus (10) comprises an ablator that is configured to generate a microporation in the area of the skin of the patient, and comprises a drug (5a), wherein the drug effects at least one of the biological regulation of at least one oocyte containing follicle, stimulation of follicle growth, induction of ovulation, promotion of gestational status, maintenance of conceptus, maintenance of pregnancy.
摘要翻译： 用于治疗患者不育症的透皮递送系统包括用于促进药物（5a）通过所述装置（10）的区域的透皮递送的装置（10），所述装置包括消融器，所述消融器构造成在 患者的皮肤，并且包含药物（5a），其中所述药物影响至少一种含卵泡的卵母细胞的生物调节，刺激卵泡生长，诱导排卵，促进妊娠状态，维持 概念，维持妊娠。
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公开(公告)号：US20090138354A1
公开(公告)日：2009-05-28
申请号：US12105199
申请日：2008-04-17
申请人： Herbert Zech
发明人： Herbert Zech
IPC分类号： G06Q50/00
摘要： A cell or tissue sample from a donor is stored in bank wherein the donor can initially determine the sample status to (a) exclusively retain, (b) make public, or (c) optionally make public his cells or tissue. Where the donor opts for optional public storage, the donor may in response to a third party request convert the optional public storage status to public status or private status top thereby share or exclusively retain his cells or tissue. Depending on the initial and/or subsequent choice by the donor, an incentive or disincentive is provided.
摘要翻译： 来自供体的细胞或组织样品储存在库中，其中供体可以最初确定样品状态，以（a）专门保留，（b）使公众，或（c）任选地公开其细胞或组织。 如果捐赠者选择公开存储，捐赠者可以响应于第三方请求，将可选的公共存储状态转换为公共状态或私人状态，从而共享或专门保留其电池或组织。 根据捐助者的初始和/或后续选择，提供奖励或抑制。
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公开(公告)号：US4008000A
公开(公告)日：1977-02-15
申请号：US601767
申请日：1975-08-04
申请人： Ottmar Gradl , Wolf Loebel , Axel Rossmann , Herbert Zech , Gerhard Zahring
发明人： Ottmar Gradl , Wolf Loebel , Axel Rossmann , Herbert Zech , Gerhard Zahring
CPC分类号： F01D5/3053
摘要： A rotor wheel including a hub in the form of a thin-walled shell. Rotor blades are arranged in an annular pattern around the axis of the hub, each blade having at least one blade root formed with a hole. A pin extends through the hole in each blade root, and at least one retaining ring coaxial with the hub axis surrounds all the pins and absorbs radial forces produced by the blades on the pins when the rotor wheel rotates. The retaining rings and blades are fixed against axial and circumferential movement with respect to the hub. A segment between each pin and retaining ring distributes the forces of the pin to the retaining ring. The pins are mounted for radial movement with respect to the hub, and one of the mounting parts for said pins may be detachable from the hub. The hub may be dish shaped, and the pins secured at only one end to the peripheral wall of the hub, that wall having axial slots so that it may expand radially.
摘要翻译： 一种转子轮，其包括薄壁壳形式的轮毂。 转子叶片围绕轮毂的轴线布置成环形图案，每个叶片具有形成有孔的至少一个叶片根部。 销延伸穿过每个叶片根部中的孔，并且与轮毂轴线同轴的至少一个保持环围绕所有销并且当转子轮旋转时吸收由销上的叶片产生的径向力。 保持环和叶片固定成相对于轮毂的轴向和周向运动。 每个销和保持环之间的一段将销的力分配到保持环。 销被安装成相对于轮毂径向移动，并且用于所述销的一个安装部分可以从轮毂拆卸。 毂可以是盘形的，并且销仅在一端固定到轮毂的周壁，该壁具有轴向槽，使得其可以径向膨胀。
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公开(公告)号：US20110014700A1
公开(公告)日：2011-01-20
申请号：US12744445
申请日：2008-11-25
申请人： Herbert Zech
发明人： Herbert Zech
IPC分类号： C12N5/07
摘要： A cell or tissue sample from a donor is stored in bank wherein the donor can initially determine the sample status to (a) exclusively retain, (b) make public, or (c) optionally make public his cells or tissue. Where the donor opts for optional public storage, the donor may in response to a third party request convert the optional public storage status to public status or private status top thereby share or exclusively retain his cells or tissue. Most preferably, depending on the initial and/or subsequent choice by the donor, an incentive or disincentive is provided.
摘要翻译： 来自供体的细胞或组织样品储存在库中，其中供体可以最初确定样品状态，以（a）专门保留，（b）使公众，或（c）任选地公开其细胞或组织。 如果捐赠者选择公开存储，捐赠者可以响应于第三方请求，将可选的公共存储状态转换为公共状态或私人状态，从而共享或专门保留其电池或组织。 最优选地，取决于供体的初始和/或随后的选择，提供了激励或抑制。
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6.发明申请METHODS AND COMPOSITION FOR COMPLEMENTING TREATMENTS TO ERADICATE NEOPLASTIC CELLS 审中-公开用于完成杀伤细胞的治疗方法和组合物公开(公告)号：US20080171022A1
公开(公告)日：2008-07-17
申请号：US11932389
申请日：2007-10-31
申请人： Herbert Zech
发明人： Herbert Zech
CPC分类号： A61K35/28
摘要： Methods and systems are provided to facilitate treatment for a neoplastic disease include providing information of stem cells that can be isolated from an individual prior to diagnosis with a neoplastic disease; processing and storing the stem cells, such as cord blood or bone marrow stem cells, in a format suitable for transfusion; providing information that treatment of the individual after diagnosis with the neoplastic disease includes bone marrow ablation in addition to at least one of surgery, chemotherapy, and radiation therapy; and releasing the stem cells for administration to the individual to repopulate the bone marrow after ablation.
摘要翻译： 提供方法和系统以促进肿瘤疾病的治疗，包括提供可在诊断前与肿瘤疾病在个体之间分离的干细胞的信息; 以适合于输血的方式处理和储存干细胞，例如脐带血或骨髓干细胞; 提供信息，除了至少一种手术，化疗和放射治疗之外，与肿瘤疾病诊断之后的个体治疗包括骨髓消融; 并释放干细胞以给予个体以在消融后重新填充骨髓。
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公开(公告)号：US4218273A
公开(公告)日：1980-08-19
申请号：US973256
申请日：1978-12-26
申请人： Wolf-Dieter Feist , Herbert Zech
发明人： Wolf-Dieter Feist , Herbert Zech
CPC分类号： B29C70/86 , B29C63/0021 , B29C70/202 , B29K2705/00 , Y10S384/905 , Y10T156/10
摘要： A structural component is made by providing a main body and applying fibre material to the body so as to adjust the coefficient of thermal expansion and/or the modulus of elasticity of the main body. If the main body is made by molding, the fibre material may be embedded in the main body while the molding material is still soft. The fibre material may be loose long fibres adhesively secured to the main body. The fibre material may be a layer having a fibre orientation arranged in the direction in which stress is experienced by the structural component and/or the direction in which expansion of the structural component is to be resisted. Several layers of fibre material may be applied to the main body with the fibre orientation of different layers being in different directions.
摘要翻译： 通过提供主体并将纤维材料施加到主体以便调节主体的热膨胀系数和/或弹性模量来制造结构部件。 如果主体通过成型制成，则纤维材料可以嵌入主体中，同时成型材料仍然柔软。 纤维材料可以是松散的长纤维，其粘合地固定到主体。 纤维材料可以是具有纤维取向布置在结构部件所经受的应力方向和/或结构部件的膨胀方向上被抵抗的层。 可以将多层纤维材料施加到主体，其中不同层的纤维取向在不同的方向。
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公开(公告)号：US08372806B2
公开(公告)日：2013-02-12
申请号：US12089445
申请日：2006-10-06
申请人： Christof Böhler , Thomas Bragagna , Reinhard Braun , Werner Braun , Herbert Zech
发明人： Christof Böhler , Thomas Bragagna , Reinhard Braun , Werner Braun , Herbert Zech
CPC分类号： A61N1/327 , A61B18/203 , A61B2017/00765 , A61B2018/00452 , A61K9/0021
摘要： The transdermal delivery system for treating infertility in a patient comprises an apparatus (10) for facilitating transdermal delivery of a drug (5a) through an area of the apparatus (10) comprises an ablator that is configured to generate a microporation in the area of the skin of the patient, and comprises a drug (5a), wherein the drug effects at least one of the biological regulation of at least one oocyte containing follicle, stimulation of follicle growth, induction of ovulation, promotion of gestational status, maintenance of conceptus, maintenance of pregnancy.
摘要翻译： 用于治疗患者不育症的经皮递送系统包括用于促进药物（5a）通过所述装置（10）的区域的透皮递送的装置（10），该装置包括消融器，所述消融器构造成在所述装置 并且包含药物（5a），其中所述药物影响至少一种含卵泡的卵母细胞的生物调节，刺激卵泡生长，诱导排卵，促进妊娠状态，维持概念， 维持妊娠。
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公开(公告)号：US20050163827A1
公开(公告)日：2005-07-28
申请号：US10832188
申请日：2004-04-26
申请人： Herbert Zech , Werner Braun
发明人： Herbert Zech , Werner Braun
CPC分类号： A61K9/703 , A61K9/7084 , A61L15/44 , A61L2300/43 , A61L2300/608
摘要： A delivery system for the transdermal administration of active ingredients in the veterinary and human medical fields, which has a cover layer (1) and is provided with an adhesive (2) for skin adhesion, the cover layer (1) being provided with a resealable filling point (4, 8) for introducing the active ingredient through the cover layer (1). The resealable filling point (4, 8) is formed in this case by a valve (4), preferably a Luer connector (4) integrated into the cover layer (1), or by a self-sealing strip (8) made of rubber and/or mixtures of rubbers, which is integrated into the cover layer (1) or attached to the cover layer (1).
摘要翻译： 一种用于在兽医和人类医学领域中透皮施用活性成分的递送系统，其具有覆盖层（1）并且设置有用于皮肤粘附的粘合剂（2），所述覆盖层（1）设置有可再密封的 用于通过覆盖层（1）引入活性成分的填充点（4,8）。 在这种情况下，可重新密封的填充点（4,8）由阀（4）形成，优选地集成在覆盖层（1）中的Luer连接器（4）或由橡胶制成的自密封条（8） 和/或橡胶的混合物，其被整合到覆盖层（1）中或附着到覆盖层（1）上。
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10.发明授权
公开(公告)号：US4271112A
公开(公告)日：1981-06-02
申请号：US50539
申请日：1979-06-21
申请人： Axel Rossman , Herbert Zech
发明人： Axel Rossman , Herbert Zech
CPC分类号： B29C70/14
摘要： Process for producing a high-strength, rotationally-symmetrical component by appending short fibers of glass, carbon or aramid in an organic solvent, and depositing the fiber material in a rotating sieve-like receptacle through a radially movable nozzle. The produced preform is impregnated with a matrix of resin and hardener and pressed into its final shape.
摘要翻译： 通过在有机溶剂中附加玻璃，碳或芳族聚酰胺的短纤维，并通过可径向移动的喷嘴将纤维材料沉积在旋转的筛状容器中来生产高强度，旋转对称的组分的方法。 生产的预成型件用树脂和硬化剂基体浸渍并压制成其最终形状。
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