发明申请
- 专利标题： Melanocortin receptor ligands
- 专利标题（中）： 黑皮质素受体配体
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申请号： US10386962申请日： 2003-03-12
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公开(公告)号： US20060128613A1公开(公告)日： 2006-06-15
- 发明人: Frank Ebetino , Adam Mazur , Jeffrey Hayes , Feng Wang , Mark Solinsky , Anny-Odile Colson , Qishen Lin
- 申请人： Frank Ebetino , Adam Mazur , Jeffrey Hayes , Feng Wang , Mark Solinsky , Anny-Odile Colson , Qishen Lin
- 专利权人： The Procter & Gamble Company
- 当前专利权人： The Procter & Gamble Company
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; C07K7/64
摘要：
Disclosed are MC-4 and/or MC-3 receptor ligands, the ligands having a structure according to Formula (I): wherein R2, R4, R4′, R5, R6, R6′, R7, R8, R8′, R9, R9′, R10, Ar, Z1, Z2, Z3, X, B, D, p, q, r and s are as described in the specification and claims, and optical isomers, diastereomers or enantiomers thereof; pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides or imides thereof. Also disclosed are pharmaceutical compositions comprising the ligands of Formula (I), as well as methods of treating diseases mediate by the MC-4/MC-3 receptors, as described in the Detailed Descriptions section of the specification.
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