发明申请
- 专利标题： PARP inhibitors
- 专利标题（中）： PARP抑制剂
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申请号： US11315528申请日： 2005-12-22
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公开(公告)号： US20060135770A1公开(公告)日： 2006-06-22
- 发明人: Muhammad Javaid , Graeme Smith , Niall Martin , Sylvie Gomez , Vincent Loh , Xiao-Ling Cockcroft , Keith Menear
- 申请人： Muhammad Javaid , Graeme Smith , Niall Martin , Sylvie Gomez , Vincent Loh , Xiao-Ling Cockcroft , Keith Menear
- 申请人地址： GB Cambridge
- 专利权人： Kudos Pharmaceuticals Ltd.
- 当前专利权人： Kudos Pharmaceuticals Ltd.
- 当前专利权人地址： GB Cambridge
- 优先权： GB0428111.9 20041222
- 主分类号： C07D403/14
- IPC分类号： C07D403/14
摘要：
A compound of the formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R2, R3, R4 and R5 are independently selected from the group consisting of H, C1-7 alkoxy, amino, halo or hydroxy; n is 1 or 2; RN1 and RN2 are independently selected from H and R, where R is optionally substituted C1-10 alkyl, C3-20 heterocyclyl and C5-20 aryl; or RN1 and RN2, together with the nitrogen atom to which they are attached form an optionally substituted 5-7 membered, nitrogen containing, heterocylic ring; Het is selected from: where Y1 and Y3 are independently selected from CH and N, Y2 is selected from CX and N and X is H, Cl or F; and where Q is O or S.
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