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33 条记录 (耗时 0.033 秒)

    PHTHALAZINONE DERIVATIVES
    2.
    发明申请
    PHTHALAZINONE DERIVATIVES 失效

    公开(公告)号：US20070093489A1

    公开(公告)日：2007-04-26

    申请号：US11550004

    申请日：2006-10-17

    申请人： Muhammad Javaid ,  Keith Menear ,  Sylvie Gomez ,  Marc Hummersone ,  Niall Martin ,  Graeme Smith ,  Xiao-Ling Cockcroft

    发明人： Muhammad Javaid ,  Keith Menear ,  Sylvie Gomez ,  Marc Hummersone ,  Niall Martin ,  Graeme Smith ,  Xiao-Ling Cockcroft

    IPC分类号： A61K31/53

    CPC分类号： C07D403/10 ,  C07D403/14 ,  C07D411/14 ,  C07D413/14 ,  C07D487/04

    摘要： A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i)  where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N; and (ii)  and where Q is O or S; RD is: wherein RN1 is selected from H and optionally substituted C1-10 alkyl; X is selected from a single bond, NRN2, CRC3RC4 and C═O; RN2 is selected from H and optionally substituted C1-10 alkyl; RC3 and RC4 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; Y is selected from NRN3 and CRC1RC2; RC1 and RC2 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; RC1 and RC2 together with the carbon atom to which they are attached may form an optionally substituted spiro-fused C5-7 carbocylic or heterocyclic ring; and when X is a single bond RN1 and RC2 may together with the N and C atoms to which they are bound, form an optionally substituted C5-7 heterocylic ring; and when X is CRC3RC4, RC2 and RC4 may together form an additional bond, such that there is a double bond between the atoms substituted by RC1 and RC3.

    Compounds
    5.
    发明申请
    Compounds 失效

    公开(公告)号：US20060199804A1

    公开(公告)日：2006-09-07

    申请号：US11361599

    申请日：2006-02-24

    申请人： Marc Hummersone ,  Sylvie Gomez ,  Keith Menear ,  Xiao-Ling Cockcroft ,  Graeme Smith

    发明人： Marc Hummersone ,  Sylvie Gomez ,  Keith Menear ,  Xiao-Ling Cockcroft ,  Graeme Smith

    IPC分类号： A61K31/551 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/53 ,  A61K31/506 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

    CPC分类号： C07D251/54 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D417/04 ,  C07D471/04

    摘要： Compounds of formula I: A-B-C  (I)and isomers, salts, solvates, chemically protected forms, and prodrugs thereof wherein: B is selected from the group consisting of:  where RN is H or Me; or B is a divalent C5 heterocyclic residue containing one or two ring heteroatoms; A is: RA3 and RA5 are independently selected from halo, ORO and RAC, where RO is H or Me, and RAC is H or C1-4 alkyl; XA is selected from N and CRA4, where RA4 is selected from H, ORO, CH2OH, CO2H, NHSO2Me and NHCOMe; RA2 and RA6 are independently selected from H, halo and ORO; or RA3 and RA4 together with the carbon atoms to which they are attached, or RA2 and RA3 together with the carbon atoms to which they are attached, may form a C5-6 heterocylic or heteroaromatic ring, containing at least one nitrogen ring atom; where if X is not N, 1, 2, or 3 of RA2 to RA6 are not H; C is:  where X is selected from N and CH, Y is selected from N and CH, and Z is selected from N and CRC6; RC3 is selected from H, halo and an optionally substituted N-containing C5-7 heterocyclic group; RC5 is a group selected from:  which group may be selected by one or two C1-4 alkyl groups or a carboxy group; RC6 is H; or, when X and Y are N, RC5 and RC6 (when Z is CRC6) together with the carbon atoms to which they are attached may form a fused C6 aromatic ring selected from the group consisting of: