发明申请
- 专利标题： Thiol-based NAALADase inhibitors
- 专利标题（中）： 基于硫醇的NAALADase抑制剂
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申请号： US11325602申请日： 2006-01-05
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公开(公告)号： US20060135812A1公开(公告)日： 2006-06-22
- 发明人: Takashi Tsukamoto , Pavel Majer , Doris Stoermer , Barbara Slusher
- 申请人： Takashi Tsukamoto , Pavel Majer , Doris Stoermer , Barbara Slusher
- 主分类号： C07D215/38
- IPC分类号： C07D215/38 ; C07D209/04 ; C07C323/16
摘要：
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
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