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    Thiolactones
    1.
    发明申请
    Thiolactones 失效
    硫内酯

    公开(公告)号：US20050004203A1

    公开(公告)日：2005-01-06

    申请号：US10791278

    申请日：2004-03-03

    Applicant: Barbara Slusher ,  Takashi Tsukamoto

    Inventor： Barbara Slusher ,  Takashi Tsukamoto

    IPC: A61K31/381 ,  A61K31/382 ,  A61K31/407 ,  C07D335/02 ,  C07D335/06 ,  C07D495/04 ,  C07D498/02

    CPC classification number: C07D335/02 ,  C07D335/06

    Abstract: This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.

    Abstract translation: 本发明提供新的化合物，药物组合物和包含这些化合物的诊断试剂，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平被改变的疾病，抑制血管发生，影响TGF-β活性或神经元活性，以及 治疗谷氨酸异常，强迫症，神经病，疼痛，前列腺疾病，癌症，亨廷顿氏病，糖尿病，视网膜病症或青光眼。

    Thiolactones
    2.
    发明申请
    Thiolactones 失效
    硫内酯

    公开(公告)号：US20080004334A1

    公开(公告)日：2008-01-03

    申请号：US11830737

    申请日：2007-07-30

    Applicant: Barbara Slusher ,  Takashi Tsukamoto

    Inventor： Barbara Slusher ,  Takashi Tsukamoto

    IPC: A61K31/381 ,  A61P25/02 ,  C07D333/32 ,  C07D333/36

    CPC classification number: C07D335/02 ,  C07D335/06

    Abstract: This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.

    Abstract translation: 本发明提供新的化合物，药物组合物和包含这些化合物的诊断试剂，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平被改变的疾病，抑制血管发生，影响TGF-β活性或神经元活性，以及 治疗谷氨酸异常，强迫症，神经病，疼痛，前列腺疾病，癌症，亨廷顿氏病，糖尿病，视网膜病症或青光眼。

    Methods Of Administering Water-Soluble Prodrugs Of Propofol For Extended Sedation
    3.
    发明申请
    Methods Of Administering Water-Soluble Prodrugs Of Propofol For Extended Sedation 审中-公开
    用于延长镇静剂的丙泊酚水溶性前药的施用方法

    公开(公告)号：US20070202158A1

    公开(公告)日：2007-08-30

    申请号：US10580405

    申请日：2004-12-17

    Applicant: Barbara Slusher ,  Krystyna Wozniak

    Inventor： Barbara Slusher ,  Krystyna Wozniak

    IPC: A61K9/48 ,  A61K9/24 ,  A61K31/66

    CPC classification number: A61K31/66 ,  A61K9/28 ,  A61K31/05 ,  C07F9/091

    Abstract: A method of administering a prodrug of propofol, preferably O-phosphonooxymethyl propofol disodium salt, comprises the oral, intragastric, or intraintestinal administration of the prodrug in amounts sufficient to induce or maintain a generalized anesthetized state, a conscious sedated state, or to treat insomnia, anxiety, nausea, vomiting, pruritus, epilepsy, and a range of pain syndromes and other medical conditions.

    Abstract translation: 给予丙泊酚前体药物，优选O-膦酰氧甲基丙泊酚二钠盐的方法包括以足以诱导或维持广泛麻醉状态，清醒镇静状态或治疗失眠的量的口服，胃内或肠内施用前药 ，焦虑，恶心，呕吐，瘙痒，癫痫，以及一系列疼痛综合症和其他医疗状况。

    Thiolactones
    5.
    发明申请
    Thiolactones 审中-公开
    硫内酯

    公开(公告)号：US20070037798A1

    公开(公告)日：2007-02-15

    申请号：US11537979

    申请日：2006-10-02

    Applicant: Barbara Slusher ,  Takashi Tsukamoto

    Inventor： Barbara Slusher ,  Takashi Tsukamoto

    IPC: A61K31/542 ,  A61K31/407 ,  A61K31/426 ,  A61K31/425 ,  A61K31/421 ,  A61K31/42 ,  C12Q1/37

    CPC classification number: C07D335/02 ,  C07D335/06

    Abstract: This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.

    Abstract translation: 本发明提供新的化合物，药物组合物和包含这些化合物的诊断试剂，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平被改变的疾病，抑制血管发生，影响TGF-β活性或神经元活性，以及 治疗谷氨酸异常，强迫症，神经病，疼痛，前列腺疾病，癌症，亨廷顿氏病，糖尿病，视网膜病症或青光眼。

    Thiol-based NAALADase inhibitors
    6.
    发明申请
    Thiol-based NAALADase inhibitors 审中-公开
    基于硫醇的NAALADase抑制剂

    公开(公告)号：US20060135812A1

    公开(公告)日：2006-06-22

    申请号：US11325602

    申请日：2006-01-05

    Applicant: Takashi Tsukamoto ,  Pavel Majer ,  Doris Stoermer ,  Barbara Slusher

    Inventor： Takashi Tsukamoto ,  Pavel Majer ,  Doris Stoermer ,  Barbara Slusher

    IPC: C07D215/38 ,  C07D209/04 ,  C07C323/16

    CPC classification number: C07C323/56 ,  C07C323/52 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65

    Abstract: This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

    Abstract translation: 本发明涉及包含这些化合物的新化合物，药物组合物和诊断试剂盒，以及使用这些化合物抑制NAALADase酶活性的方法，检测其中NAALADase水平被改变，影响神经元活性，影响TGF-β活性，抑制血管生成和治疗 谷氨酸异常，糖尿病性神经病，疼痛，强迫症，前列腺疾病，癌症和青光眼。

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