发明申请
US20060160173A1 Feedback-resistant homoserine transsuccinylases having a modified c terminus
失效
具有修饰的c末端的反馈抗高丝氨酸转氨基酰基酶
- 专利标题： Feedback-resistant homoserine transsuccinylases having a modified c terminus
- 专利标题（中）： 具有修饰的c末端的反馈抗高丝氨酸转氨基酰基酶
-
申请号： US10530844申请日： 2003-10-16
-
公开(公告)号： US20060160173A1公开(公告)日： 2006-07-20
- 发明人: Susanne Leonhartsberger , Christoph Winterhalter , Kerstin Pfeiffer , Brigitte Bauer
- 申请人： Susanne Leonhartsberger , Christoph Winterhalter , Kerstin Pfeiffer , Brigitte Bauer
- 优先权： DE10249642.0 20021024
- 国际申请： PCT/EP03/11486 WO 20031016
- 主分类号： C12P21/06
- IPC分类号： C12P21/06 ; C07H21/04 ; C12N9/10 ; C12N15/74 ; C12N1/21
摘要：
The invention relates to a homoserine transsuccinylase, which exhibits reduced sensitivity towards L-methionine or SAM in comparison with a homoserine transsuccinylase wild-type enzyme, whereby the latter comprises an amino acid sequence containing a TyrGlnXaaThrPro sub-sequence, the Thr of said sub-sequence lying between positions 285 and 310 of the amino acid sequence and position 1 being filled by the starter methionine. The inventive homoserine transsuccinylase is characterized in that in comparison with the wild-type enzyme at least 2 amino acids are modified, said modification taking place in the Thr of the sub-sequence or in the C-terminal.
公开/授权文献
信息查询
