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发明申请
US20060167030A1 Sulfonamido-macrocycles and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof 审中-公开
磺酰胺 - 大环化合物及其盐，包含这些化合物的药物组合物，其制备方法和用途

Sulfonamido-macrocycles and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof
摘要：
The invention relates to sulfonamido-macrocycles according to the general Formula I and the salts thereof, to pharmaceutical compositions comprising the sulfonamido-macrocycles and to a method of preparing the sulfonamido-macrocycles as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling. wherein R1, R2 and R3 have the meaning as given in the specification and the claims.
摘要（中）：

本发明涉及根据通式I的磺酰胺 - 大环化合物及其盐，涉及包含磺酰氨基 - 大环化合物的药物组合物以及制备磺酰氨基 - 大环化合物的方法及其用于制备用于治疗的药物组合物的用途 的血管生长失调的疾病或伴随血管生成紊乱的疾病，其中所述化合物有效地干扰血管生成素并因此影响Tie2信号传导。 其中R 1，R 2，R 3和R 3具有说明书和权利要求书中给出的含义。

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