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1.发明申请Sulfonamido-macrocycles and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof 审中-公开磺酰胺 - 大环化合物及其盐，包含这些化合物的药物组合物，其制备方法和用途公开(公告)号：US20060167030A1
公开(公告)日：2006-07-27
申请号：US11312646
申请日：2005-12-21
申请人： Georg Kettschau , Hans Briem , Andreas Huth , Ulrich Luecking , Martina Schaefer , Karl-Heinz Thierauch , Wolfgang Schwede , Manfred Husemann
发明人： Georg Kettschau , Hans Briem , Andreas Huth , Ulrich Luecking , Martina Schaefer , Karl-Heinz Thierauch , Wolfgang Schwede , Manfred Husemann
IPC分类号： A61K31/519 , C07D498/04
CPC分类号： C07D513/08
摘要： The invention relates to sulfonamido-macrocycles according to the general Formula I and the salts thereof, to pharmaceutical compositions comprising the sulfonamido-macrocycles and to a method of preparing the sulfonamido-macrocycles as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling. wherein R1, R2 and R3 have the meaning as given in the specification and the claims.
摘要翻译： 本发明涉及根据通式I的磺酰胺 - 大环化合物及其盐，涉及包含磺酰氨基 - 大环化合物的药物组合物以及制备磺酰氨基 - 大环化合物的方法及其用于制备用于治疗的药物组合物的用途 的血管生长失调的疾病或伴随血管生成紊乱的疾病，其中所述化合物有效地干扰血管生成素并因此影响Tie2信号传导。 其中R 1，R 2，R 3和R 3具有说明书和权利要求书中给出的含义。
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2.发明申请Sulfoximine-macrocycle compounds and salts thereof, pharmaceutical compositions comprising said compounds, methods of preparing same and uses of same 审中-公开磺酰亚胺 - 大环化合物及其盐，包含所述化合物的药物组合物，其制备方法及其用途公开(公告)号：US20060252782A1
公开(公告)日：2006-11-09
申请号：US11399619
申请日：2006-04-07
申请人： Ulrich Luecking , Georg Kettschau , Hans Briem , Wolfgang Schwede , Martina Schaefer , Karl-Heinz Thierauch , Manfred Husemann
发明人： Ulrich Luecking , Georg Kettschau , Hans Briem , Wolfgang Schwede , Martina Schaefer , Karl-Heinz Thierauch , Manfred Husemann
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： C07D209/48 , C07D239/42 , C07D513/08
摘要： The invention relates to macrocyctic sulfoximines of the general Formula I: wherein A, X, Y, R1, R2 and R3 have the meaning as given in the specification and the claims, and to salts thereof; to pharmaceutical compositions comprising the macrocyclic sulfoximines, and to a method of preparing the macrocyclic sulfoximines, as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.
摘要翻译： 本发明涉及通式I的大环氰基亚砜：其中A，X，Y，R 1，R 2和R 3具有 在说明书和权利要求书中给出的含义及其盐; 涉及包含大环亚磺酰亚胺的药物组合物，以及制备大环亚砜亚胺的方法及其制备用于治疗失调血管生长疾病的药物组合物或伴有血管生长失调的疾病的用途，其中 该化合物有效地干扰血管生成素，因此影响Tie2信号。
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3.发明申请Sulfonamido-macrocycles as Tie2 inhibitors and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof 审中-公开作为Tie2抑制剂的磺酰胺 - 大环化合物及其盐，包含这些化合物的药物组合物，其制备方法及其应用公开(公告)号：US20060194823A1
公开(公告)日：2006-08-31
申请号：US11312648
申请日：2005-12-21
申请人： Georg Kettschau , Hans Briem , Ingo Hartung , Ulrich Luecking , Martina Schaefer , Karl-Heinz Thierauch , Wolfgang Schwede , Manfred Husemann
发明人： Georg Kettschau , Hans Briem , Ingo Hartung , Ulrich Luecking , Martina Schaefer , Karl-Heinz Thierauch , Wolfgang Schwede , Manfred Husemann
IPC分类号： A61K31/519 , C07D498/14
CPC分类号： C07D513/08
摘要： The invention relates to sulfonamido-macrocycles according to the general Formula I and the salts thereof, to pharmaceutical compositions comprising the sulfonamido-macrocycles and to a method of preparing the sulfonamido-macrocycles as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling. wherein R1, R2, R4, A, X, Y, Z and m have the meaning as given in the specification and the claims.
摘要翻译： 本发明涉及根据通式I的磺酰胺 - 大环化合物及其盐，涉及包含磺酰氨基 - 大环化合物的药物组合物以及制备磺酰氨基 - 大环化合物的方法及其用于制备用于治疗的药物组合物的用途 的血管生长失调的疾病或伴随血管生成紊乱的疾病，其中所述化合物有效地干扰血管生成素并因此影响Tie2信号传导。 其中R 1，R 2，R 4，A，X，Y，Z和m具有说明书中给出的含义，并且 声称。
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4.发明授权Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same 有权吡唑并吡啶及其盐，包含所述化合物的药物组合物，其制备方法和用途公开(公告)号：US07842809B2
公开(公告)日：2010-11-30
申请号：US11337114
申请日：2006-01-23
申请人： Wolfgang Schwede , Hans Briem , Hermann Kuenzer , Manfred Husemann , Georg Kettschau , Martina Schaefer , Antonius Ter Laak , Karl-Heinz Thierauch , Stuart James Ince
发明人： Wolfgang Schwede , Hans Briem , Hermann Kuenzer , Manfred Husemann , Georg Kettschau , Martina Schaefer , Antonius Ter Laak , Karl-Heinz Thierauch , Stuart James Ince
IPC分类号： C07D513/02
CPC分类号： C07D471/04
摘要： The invention relates to pyrazolopyridines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.
摘要翻译： 本发明涉及根据通式（I）的吡唑并吡啶及其盐，其包含所述吡唑并吡啶的药物组合物和制备所述吡唑并吡啶的方法及其用于制备用于治疗失调的疾病的药物组合物的用途 血管生长或伴随血管生长失调的疾病，其中所述化合物有效地干扰血管生成素并因此影响Tie2信号传导。
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5.发明申请Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same 有权吡唑并吡啶及其盐，包含所述化合物的药物组合物，其制备方法和用途公开(公告)号：US20060252754A1
公开(公告)日：2006-11-09
申请号：US11337114
申请日：2006-01-23
申请人： Wolfgang Schwede , Hans Briem , Hermann Kuenzer , Manfred Husemann , Georg Kettschau , Martina Schaefer , Antonius Ter Laak , Karl-Heinz Thierauch , Stuart Ince
发明人： Wolfgang Schwede , Hans Briem , Hermann Kuenzer , Manfred Husemann , Georg Kettschau , Martina Schaefer , Antonius Ter Laak , Karl-Heinz Thierauch , Stuart Ince
IPC分类号： A61K31/53 , A61K31/506 , A61K31/497 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The invention relates to pyrazolopyridines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.
摘要翻译： 本发明涉及根据通式（I）的吡唑并吡啶及其盐，其包含所述吡唑并吡啶的药物组合物和制备所述吡唑并吡啶的方法及其用于制备用于治疗失调的疾病的药物组合物的用途 血管生长或伴随血管生长失调的疾病，其中所述化合物有效地干扰血管生成素并因此影响Tie2信号传导。
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![Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments](/abs-image/US/2007/04/26/US20070093490A1/abs.jpg.150x150.jpg)
6.发明申请Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments 失效取代的咪唑并[1,2b]哒嗪作为激酶抑制剂，其制备和用作药物公开(公告)号：US20070093490A1
公开(公告)日：2007-04-26
申请号：US11514308
申请日：2006-09-01
申请人： Olaf Prien , Stuart Ince , Knut Eis , Christoph Huwe , Ulrich Lucking , Rolf Jautelat , Ulrich Zugel , Judith Gunther , Benjamin Bader , Manfred Husemann , Karina Schuck
发明人： Olaf Prien , Stuart Ince , Knut Eis , Christoph Huwe , Ulrich Lucking , Rolf Jautelat , Ulrich Zugel , Judith Gunther , Benjamin Bader , Manfred Husemann , Karina Schuck
IPC分类号： A61K31/503 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel inhibitors of kinases, methods for preparing such inhibitors, intermediates for the preparation of such inhibitors and uses of such inhibitors.
摘要翻译： 本发明涉及新型的激酶抑制剂，制备这种抑制剂的方法，制备这种抑制剂的中间体和这种抑制剂的用途。
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![Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments](/abs-image/US/2010/07/06/US07750000B2/abs.jpg.150x150.jpg)
7.发明授权Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments 失效取代的咪唑并[1,2b]哒嗪作为激酶抑制剂，其制备和用作药物公开(公告)号：US07750000B2
公开(公告)日：2010-07-06
申请号：US11514308
申请日：2006-09-01
申请人： Olaf Prien , Stuart James Ince , Knut Eis , Christoph Huwe , Ulrich Lücking , Rolf Jautelat , Ulrich Zügel , Judith Günther , Benjamin Bader , Manfred Husemann , Karina Schuck
发明人： Olaf Prien , Stuart James Ince , Knut Eis , Christoph Huwe , Ulrich Lücking , Rolf Jautelat , Ulrich Zügel , Judith Günther , Benjamin Bader , Manfred Husemann , Karina Schuck
IPC分类号： A61K31/4985 , A61K31/5355 , C07D487/04 , C07D413/12 , A61P3/10 , A61P11/06 , A61P29/00 , A61P17/06 , A61P17/00
CPC分类号： C07D487/04
摘要： The invention relates to novel inhibitors of kinases, and pharmaceutical compositions comprising them. The inhibitors are substituted imidazo[1,2b]pyridazines.
摘要翻译： 本发明涉及新型的激酶抑制剂和包含它们的药物组合物。 抑制剂是取代的咪唑并[1,2b]哒嗪。
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8.发明申请PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME 审中-公开吡唑并嘧啶及其盐，其包含其的药物组合物，其制备方法及其用途公开(公告)号：US20080039455A1
公开(公告)日：2008-02-14
申请号：US11765647
申请日：2007-06-20
申请人： Stuart Ince , Olaf Prien , Shoufu Lu , Hongyi Yu , Manfred Husemann , Karina Schuck
发明人： Stuart Ince , Olaf Prien , Shoufu Lu , Hongyi Yu , Manfred Husemann , Karina Schuck
IPC分类号： A61K31/519 , A61K31/5377 , A61P29/00 , A61P35/00 , A61P9/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to pyrazolopyrimidines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyrimidines and to a method of preparing said pyrazolopyrimidines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment or prophylaxis of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth
摘要翻译： 本发明涉及根据通式（I）的吡唑并嘧啶及其盐，其包含所述吡唑并嘧啶的药物组合物和制备所述吡唑并嘧啶的方法及其用于制备用于治疗或预防疾病的药物组合物的用途 的血管生长失调或伴随血管生长失调的疾病
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