- 专利标题： Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
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申请号： US11417447申请日： 2006-05-03
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公开(公告)号： US20060205780A1公开(公告)日： 2006-09-14
- 发明人: Mikkel Thygesen , Nathalie Schlienger , Bo-Ragnar Tolf , Carl-Magnus Andersson , Fritz Blatter , Jorg Berghausen
- 申请人： Mikkel Thygesen , Nathalie Schlienger , Bo-Ragnar Tolf , Carl-Magnus Andersson , Fritz Blatter , Jorg Berghausen
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; C07D211/06
摘要：
Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
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