-
公开(公告)号：US08680115B2
公开(公告)日：2014-03-25
申请号：US12473220
申请日：2009-05-27
IPC分类号： A61P43/00 , A61K31/435 , C07D401/04 , C07D413/06 , C07D417/06 , C07D451/02 , C07D513/04
CPC分类号： C07D413/06 , C07D401/04 , C07D401/06 , C07D417/06 , C07D451/02 , C07D451/04 , C07D451/06
摘要： The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
摘要翻译： 本发明涉及四氢喹啉化合物作为毒蕈碱受体激动剂; 包含它们的组合物; 用所述化合物抑制毒蕈碱受体的活性的方法; 使用所述化合物治疗与毒蕈碱受体相关的疾病状况的方法; 以及用于鉴定适于使用所述化合物治疗的受试者的方法。
-
公开(公告)号：US20080070948A1
公开(公告)日：2008-03-20
申请号：US11945857
申请日：2007-11-27
申请人： Nicholas Kelly , Kristian Koch , Bo-Ragnar Tolf
发明人： Nicholas Kelly , Kristian Koch , Bo-Ragnar Tolf
IPC分类号： A61K31/4535 , A61K31/404 , A61K31/423 , A61P25/00 , C07D209/04 , C07D235/04 , C07D277/62 , C07D263/54 , C07D211/06 , A61P27/00 , A61K31/454 , A61K31/428
CPC分类号： C07D451/02 , A61K31/404 , A61K31/4164 , A61K31/421 , A61K31/426 , A61K31/445 , C07D209/08 , C07D209/34 , C07D209/38 , C07D235/26 , C07D263/58 , C07D277/68 , C07D401/06 , C07D413/06 , C07D417/06
摘要： Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
摘要翻译： 增加乙酰胆碱信号传导或在脑中的作用的苯并咪唑烷酮衍生物化合物，以及高度选择性的毒蕈碱激动剂，特别是对M 1 N 1和/或M 4 H 4受体亚型的药物组合物，其包含 公开了使用这些化合物治疗精神病的方法。
-
3.发明申请SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS 有权N-（4-氟甲基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙烯酰）苯基甲基）氨基甲酸酯及其盐酸盐和结晶形式的合成公开(公告)号：US20070260064A1
公开(公告)日：2007-11-08
申请号：US11749115
申请日：2007-05-15
IPC分类号： C07D211/98
CPC分类号： C07D211/58
摘要： Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
摘要翻译： 本文公开了合成N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基）苯基甲基）脲的方法。 本文还公开了N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基） - 苯基甲基）脲的半酒石酸盐，以及获得 盐。 进一步公开的是N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基）苯基甲基）氨基酰胺及其半酒石酸盐的各种结晶形式，包括各种多晶型物 并解决。
-
公开(公告)号：US07291611B2
公开(公告)日：2007-11-06
申请号：US11188295
申请日：2005-07-21
IPC分类号： A01N43/00 , A01K31/395
CPC分类号： C07D209/08 , C07D209/34 , C07D209/38 , C07D235/26 , C07D263/58 , C07D277/68 , C07D401/06 , C07D413/06 , C07D417/06 , C07D451/02 , C07D471/08
摘要： Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
-
5.发明申请Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms 审中-公开N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基）苯基甲基）脲和其酒石酸盐和结晶形式的合成公开(公告)号：US20060205781A1
公开(公告)日：2006-09-14
申请号：US11418341
申请日：2006-05-03
申请人： Mikkel Thygesen , Nathalie Schlienger , Bo-Ragnar Tolf , Carl-Magnus Andersson , Fritz Blatter , Jorg Berghausen
发明人： Mikkel Thygesen , Nathalie Schlienger , Bo-Ragnar Tolf , Carl-Magnus Andersson , Fritz Blatter , Jorg Berghausen
IPC分类号： A61K31/445 , C07D211/54
CPC分类号： C07D211/58
摘要： Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
摘要翻译： 本文公开了合成N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基） - 苯基甲基）脲的方法。 本文还公开了N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基） - 苯基甲基）脲的半酒石酸盐，以及获得 盐。 进一步公开的是N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基） - 苯基甲基）氨基脲及其半酒石酸盐的各种结晶形式，包括各种 多晶型物和溶剂化物。
-
公开(公告)号：US20060199813A1
公开(公告)日：2006-09-07
申请号：US11417865
申请日：2006-05-03
IPC分类号： A61K31/5415 , A61K31/538 , C07D417/02 , C07D413/02
CPC分类号： C07D451/02 , C07D401/04 , C07D413/06 , C07D417/06 , C07D513/04
摘要： The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
-
7.发明授权Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms 有权N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基）苯基甲基）脲和其酒石酸盐和结晶形式的合成公开(公告)号：US07790899B2
公开(公告)日：2010-09-07
申请号：US11749115
申请日：2007-05-15
IPC分类号： C07D211/98
CPC分类号： C07D211/58
摘要： Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
摘要翻译： 本文公开了合成N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基）苯基甲基）脲的方法。 本文还公开了N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基） - 苯基甲基）脲的半酒石酸盐，以及获得 盐。 进一步公开的是N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基）苯基甲基）氨基酰胺及其半酒石酸盐的各种结晶形式，包括各种多晶型物 并解决。
-
公开(公告)号：US20080009520A1
公开(公告)日：2008-01-10
申请号：US11858828
申请日：2007-09-20
申请人： Nicholas Kelly , Kristian Koch , Bo-Ragnar Tolf
发明人： Nicholas Kelly , Kristian Koch , Bo-Ragnar Tolf
IPC分类号： A61K31/445 , A61K31/404 , A61K31/4164 , A61P25/00 , A61P25/28 , A61K31/421 , A61K31/426
CPC分类号： C07D451/02 , A61K31/404 , A61K31/4164 , A61K31/421 , A61K31/426 , A61K31/445 , C07D209/08 , C07D209/34 , C07D209/38 , C07D235/26 , C07D263/58 , C07D277/68 , C07D401/06 , C07D413/06 , C07D417/06
摘要： Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
-
公开(公告)号：US07307075B2
公开(公告)日：2007-12-11
申请号：US10329455
申请日：2002-12-23
IPC分类号： A61P25/00 , A61K31/535 , C07D265/36
CPC分类号： C07D451/02 , C07D401/04 , C07D413/06 , C07D417/06 , C07D513/04
摘要： The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
摘要翻译： 本发明涉及四氢喹啉化合物作为毒蕈碱受体激动剂; 包含它们的组合物; 用所述化合物抑制毒蕈碱受体的活性的方法; 使用所述化合物治疗与毒蕈碱受体相关的疾病状况的方法; 以及用于鉴定适于使用所述化合物治疗的受试者的方法。
-
10.发明申请Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof 审中-公开固体N-去甲基氯氮平的合成和分离方法及其结晶形式公开(公告)号：US20060199808A1
公开(公告)日：2006-09-07
申请号：US11417071
申请日：2006-05-03
IPC分类号： A61K31/551 , C07D403/04
CPC分类号： C07D243/38
摘要： Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
摘要翻译： 本文公开了N-去甲基氯氮平的结晶形式A，B，C，D和E，其制备方法，包含其的药物组合物和涉及N-去甲基氯氮平多形态的治疗方法。
-
-
-
-
-
-
-
-
-
搜索结果
37 条记录 (耗时 0.032 秒)
