发明申请
US20060241132A1 Spiro derivatives and adhesion molecule inhibitors comprising the same as active ingredient
审中-公开
包含与活性成分相同的螺衍生物和粘附分子抑制剂
- 专利标题： Spiro derivatives and adhesion molecule inhibitors comprising the same as active ingredient
- 专利标题（中）： 包含与活性成分相同的螺衍生物和粘附分子抑制剂
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申请号： US10508500申请日： 2003-03-19
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公开(公告)号： US20060241132A1公开(公告)日： 2006-10-26
- 发明人: Takeshi Ishigaki , Koji Taniguchi , Aki Taniguchi , Mie Kainoh , Hiroyuki Meguro , Yoko Ishizaka
- 申请人： Takeshi Ishigaki , Koji Taniguchi , Aki Taniguchi , Mie Kainoh , Hiroyuki Meguro , Yoko Ishizaka
- 申请人地址： JP Tokyo 103-8666
- 专利权人： Toray Industries, Inc. A Corporation of Japan
- 当前专利权人： Toray Industries, Inc. A Corporation of Japan
- 当前专利权人地址： JP Tokyo 103-8666
- 优先权： JP2002-80697 20020322
- 国际申请： PCT/JP03/03324 WO 20030319
- 主分类号： A61K31/4747
- IPC分类号： A61K31/4747 ; C07D498/10
摘要：
Disclosed is the use of an adhesion molecule inhibitor that is effective in the prevention and treatment of inflammatory diseases caused by infiltration of leukocytes such as monocytes, lymphocytes and eosindphils, by inhibiting cell infiltration which mediates adhesion molecules, especially adhesion molecule VLA-4. Since the spiro acid derivatives according to the present invention are excellent in the effect of inhibiting cell adhesion via adhesion molecules, especially adhesion molecule VLA-4, they are useful as therapeutic drugs against various inflammatory diseases. For example, provided are the spiro derivative and the adhesion molecule inhibitor which includes as an active ingredient the spiro derivative as shown by the below formula (18).
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