公开(公告)号：US20060241132A1

公开(公告)日：2006-10-26

申请号：US10508500

申请日：2003-03-19

申请人： Takeshi Ishigaki ,  Koji Taniguchi ,  Aki Taniguchi ,  Mie Kainoh ,  Hiroyuki Meguro ,  Yoko Ishizaka

发明人： Takeshi Ishigaki ,  Koji Taniguchi ,  Aki Taniguchi ,  Mie Kainoh ,  Hiroyuki Meguro ,  Yoko Ishizaka

IPC分类号： A61K31/4747 ,  C07D498/10

CPC分类号： C07K5/06139 ,  C07D471/10

摘要： Disclosed is the use of an adhesion molecule inhibitor that is effective in the prevention and treatment of inflammatory diseases caused by infiltration of leukocytes such as monocytes, lymphocytes and eosindphils, by inhibiting cell infiltration which mediates adhesion molecules, especially adhesion molecule VLA-4. Since the spiro acid derivatives according to the present invention are excellent in the effect of inhibiting cell adhesion via adhesion molecules, especially adhesion molecule VLA-4, they are useful as therapeutic drugs against various inflammatory diseases. For example, provided are the spiro derivative and the adhesion molecule inhibitor which includes as an active ingredient the spiro derivative as shown by the below formula (18).

摘要翻译： 公开了通过抑制介导粘附分子特别是粘附分子VLA-4的细胞浸润，有效地预防和治疗由白细胞如单核细胞，淋巴细胞和嗜酸性粒细胞浸润引起的炎性疾病的粘附分子抑制剂的用途。 由于根据本发明的螺酸衍生物通过粘附分子特别是粘附分子VLA-4抑制细胞粘附的效果优异，因此它们可用作抗各种炎性疾病的治疗药物。 例如，可列举如下式（18）所示的作为活性成分的螺衍生物的螺衍生物和粘附分子抑制剂。