摘要:
Disclosed is the use of an adhesion molecule inhibitor that is effective in the prevention and treatment of inflammatory diseases caused by infiltration of leukocytes such as monocytes, lymphocytes and eosindphils, by inhibiting cell infiltration which mediates adhesion molecules, especially adhesion molecule VLA-4. Since the spiro acid derivatives according to the present invention are excellent in the effect of inhibiting cell adhesion via adhesion molecules, especially adhesion molecule VLA-4, they are useful as therapeutic drugs against various inflammatory diseases. For example, provided are the spiro derivative and the adhesion molecule inhibitor which includes as an active ingredient the spiro derivative as shown by the below formula (18).
摘要:
Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by the following Formula (31):
摘要:
A semiconductor integrated circuit according to an example of the present invention includes a first interconnect extending in a first direction, a second interconnect arranged over the first interconnect and extending in a second direction intersecting the first direction, a first via for connecting a first contact part of the first interconnect and a second contact part of the second interconnect, and a second via for connecting a third contact part of the first interconnect and a fourth contact part of the second interconnect. The first and third contact parts are arranged by being aligned in the first direction, and the second and fourth contact parts are arranged by being aligned in the second direction.
摘要:
A semiconductor integrated circuit device includes a semiconductor substrate having a first area. A first counter is provided in the first area, cyclically counts and outputs a first counter signal as a result of counting. A global reset circuit is provided on the semiconductor substrate and outputs a global reset signal. A first local reset circuit is provided in the first area and outputs a first local reset signal upon receiving the first counter signal of a set value after supplied with the global reset signal. A first circuit is provided in the first area and supplied with the first local reset signal.
摘要:
A light emitting device material containing a pyrene compound of formula (1) and a light emitting device. In formula (1), R1 to R18 are the same or different and are selected from hydrogen, alkyl, cycloalkyl, heterocyclic, alkenyl, cycloalkenyl, alkynyl, alkoxy, alkylthio, arylether, arylthioether, aryl, heteroaryl, halogen, carbonyl, carboxyl, oxycarbonyl, carbamoyl, amino, phosphine oxide and silyl; adjacent substituents among R1 to R18 may be combined with each other to form a ring; n represents an integer of 1 to 3; X is —O—, —S— or —NR19—; R19 is selected from hydrogen, alkyl, cycloalkyl, heterocyclic, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl or amino; R19 may be combined with R11 or R18 to form a ring; Y is a single bond, arylene or heteroarylene; and n substituents among R1 to R10 and any one of R11 to R19 are used for linkage with Y
摘要:
A method for designing a semiconductor integrated circuit, includes placing first, second and third cells, respectively including first stage synchronous circuit having signal propagation time, second stage synchronous circuit having a signal propagation time almost equal to the first stage synchronous circuit, and logic circuit; routing wirings so as to electrically connect the first to third cells; verifying signal propagation timing of the semiconductor integrated circuit having the first to third cells; adjusting the signal propagation timing based on critical path of the signal propagation timing of the semiconductor integrated circuit; and extracting the critical path to replace the second stage synchronous circuit by synchronous circuit of different synchronous type from the first stage synchronous circuit so as to provide a shorter signal propagation time than the first stage synchronous circuit.
摘要:
A semiconductor integrated circuit according to an example of the present invention includes a first interconnect extending in a first direction, a second interconnect arranged over the first interconnect and extending in a second direction intersecting the first direction, a first via for connecting a first contact part of the first interconnect and a second contact part of the second interconnect, and a second via for connecting a third contact part of the first interconnect and a fourth contact part of the second interconnect. The first and third contact parts are arranged by being aligned in the first direction, and the second and fourth contact parts are arranged by being aligned in the second direction.
摘要:
A semiconductor integrated circuit device includes a semiconductor substrate having a first area. A first counter is provided in the first area, cyclically counts and outputs a first counter signal as a result of counting. A global reset circuit is provided on the semiconductor substrate and outputs a global reset signal. A first local reset circuit is provided in the first area and outputs a first local reset signal upon receiving the first counter signal of a set value after supplied with the global reset signal. A first circuit is provided in the first area and supplied with the first local reset signal.
摘要:
The invention provides a light emitting device having a low driving voltage and excellent durability by a material for a light emitting device expressed by the general formula (1): where in each of R1, R2, R3, R4, R5 and R6 may be the same or different and is selected from hydrogen, an alkyl group, and an aryl group, A represents an n-valent aromatic hydrocarbon group, B represents an alkyl group or an aryl group, X represents carbon or nitrogen, n represents a natural number from 2 to 6, and n substituents having a phenanthroline skeleton or a benzoquinoline skeleton may be the same or different.
摘要:
A semiconductor system includes a plurality of semiconductor chips, a first group of wirings, a second group of wirings and a connection rearrange wiring section. The first group of wirings interconnect the plurality of semiconductor chips. The second group of wirings are used for redundancy and interconnect the plurality of semiconductor chips. The connection rearrange wiring section includes a connection test circuit and connection rearrange circuit. The connection test circuit makes a test for connection between the plurality of semiconductor chips by means of the first group of wirings. The connection rearrange circuit makes unusable a wiring of the first group in which poor connection occurs and rearranges the connection between the semiconductor chips by use of the wiring of the second group when the poor connection is detected in the wiring of the first group by the connection test circuit.