发明申请
US20070020635A1 Nucleotides for prevention and treatment of bacterial and fungal pathologies
有权
用于预防和治疗细菌和真菌病理学的核苷酸
- 专利标题： Nucleotides for prevention and treatment of bacterial and fungal pathologies
- 专利标题（中）： 用于预防和治疗细菌和真菌病理学的核苷酸
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申请号： US10574254申请日： 2004-06-03
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公开(公告)号： US20070020635A1公开(公告)日： 2007-01-25
- 发明人: Yin Chen , Xin Tan
- 申请人： Yin Chen , Xin Tan
- 申请人地址： US TX Houston 77042
- 专利权人： CytoGenix, Inc.
- 当前专利权人： CytoGenix, Inc.
- 当前专利权人地址： US TX Houston 77042
- 优先权： US10/453,410 20030603; US10/743,956 20031223; US10/818,158 20040405
- 国际申请： PCT/US04/17331 WO 20040603
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C40B40/02 ; C40B40/08 ; C07H21/04 ; A61K48/00 ; C12N15/74
摘要：
A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial and fungal gene(s) related to cell growth and toxin production and secretion. The screening library is used to, among other things, identify ODNs effective in stopping cell growth, killing bacteria or fungi, or preventing bacteria and/or fungi from synthesizing and secreting their toxins, and/or to discover ODNs effective in eukaryotic (e.g., mammalian) cells for targeted alteration of gene function. The library is also useful for identifying ssDNAs or ODNs that are used as therapeutic agents for, for instance, providing a method for treatment of bacterial infections such as sepsis.
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