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1.发明申请公开(公告)号：US20050020526A1
公开(公告)日：2005-01-27
申请号：US10818158
申请日：2004-04-05
IPC: A61K48/00 , C07H21/04 , C09D7/00 , C12N1/21 , C12N5/071 , C12N5/10 , C12N15/10 , C12N15/113 , C12N15/63 , C12N15/74 , C12Q1/68 , C12N5/08
CPC classification number: C12N15/113 , C07H21/04 , C12N15/1034 , C12N15/111 , C12N15/74 , C12N2310/11 , C12N2310/111 , C12N2310/127 , C12N2320/11 , C12N2330/31 , C12Q1/6837 , C12Q2565/531
Abstract: A method for producing ODNs in bacterial or fungal cells in vivo for treatment of sepsis so that, when the ODNs reach and knock down their target genes, and thereby kill bacterial or fungal cells or inhibit their growth, the bacterial or fungal accumulation in the bloodstream is held constant or diminished and the sepsis syndrome is reduced or eliminated. The invention also contemplates of certain ODNs for use in treatment of sepsis.
Abstract translation: 用于在体内在细菌或真菌细胞中产生ODN的方法，用于治疗败血症，使得当ODN达到并击倒其靶基因，从而杀死细菌或真菌细胞或抑制其生长时，血液中的细菌或真菌积累 保持不变或减少，败血症综合征减少或消除。 本发明还考虑用于治疗败血症的某些ODN。
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2.发明申请公开(公告)号：US20070020635A1
公开(公告)日：2007-01-25
申请号：US10574254
申请日：2004-06-03
CPC classification number: C12N15/113 , C07H21/04 , C12N15/1034 , C12N15/111 , C12N15/74 , C12N2310/11 , C12N2310/111 , C12N2310/127 , C12N2320/11 , C12N2330/31 , C12Q1/6837 , C12Q2565/531
Abstract: A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial and fungal gene(s) related to cell growth and toxin production and secretion. The screening library is used to, among other things, identify ODNs effective in stopping cell growth, killing bacteria or fungi, or preventing bacteria and/or fungi from synthesizing and secreting their toxins, and/or to discover ODNs effective in eukaryotic (e.g., mammalian) cells for targeted alteration of gene function. The library is also useful for identifying ssDNAs or ODNs that are used as therapeutic agents for, for instance, providing a method for treatment of bacterial infections such as sepsis.
Abstract translation: 选择性诱导型单链DNA（ssDNA）表达文库，构建ssDNA表达文库的方法，使用表达文库筛选ssDNA的方法以及鉴定改变细菌和真菌基因表达的ssDNA分子的方法 ）与细胞生长和毒素生成和分泌有关。 除了别的以外，筛选文库用于鉴别有效阻止细胞生长，杀死细菌或真菌，或阻止细菌和/或真菌合成和分泌其毒素的ODN，和/或发现在真核生物中有效的ODN（例如， 哺乳动物）细胞用于靶向改变基因功能。 该文库也可用于鉴定用作治疗剂的ssDNA或ODN，例如提供治疗细菌感染如败血症的方法。
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3.发明申请Oligodoxynucleotide (ODN) libraries, their use in screening for antibacterial agents, and catalytic ODN sequence for use as an antibacterial agent 审中-公开寡核苷酸（ODN）文库，它们在抗菌剂筛选中的应用，以及用作抗菌剂的催化ODN序列公开(公告)号：US20050136393A1
公开(公告)日：2005-06-23
申请号：US10743956
申请日：2003-12-23
CPC classification number: C12Q1/18
Abstract: A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial gene(s) related to cell growth and toxin production and secretion. The screening library is used to, among other things, identify ODNs effective in stopping bacterial growth, killing bacteria or preventing bacteria from synthesizing and secreting their toxins, and/or to discover ODNs effective in eukaryotic (e.g., mammalian) cells for targeted alteration of gene function. The library is also useful for identifying ssDNAs or ODNs that are used as therapeutic antibacterial reagents, for identifying essential bacterial genes that can serve as targets for antibiotic discovery, and for providing a method for treatment of bacterial infections.
Abstract translation: 选择性诱导型单链DNA（ssDNA）表达文库，构建ssDNA表达文库的方法，使用表达文库筛选ssDNA的方法以及鉴定改变细菌基因表达的ssDNA分子的方法 细胞生长和毒素生成和分泌。 除了别的以外，筛选文库用于鉴别有效阻止细菌生长，杀死细菌或防止细菌合成和分泌其毒素的ODN，和/或发现在真核（例如哺乳动物）细胞中有效的ODN，用于靶向改变 基因功能。 该文库还可用于鉴定用作治疗性抗菌试剂的ssDNA或ODN，用于鉴定可用作抗生素发现靶标的重要细菌基因，以及提供治疗细菌感染的方法。
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公开(公告)号：US09982117B2
公开(公告)日：2018-05-29
申请号：US15024557
申请日：2014-09-26
Applicant: Li Jia , Gary Hamed , Xin Tan
Inventor： Li Jia , Gary Hamed , Xin Tan
CPC classification number: C08L19/006 , C08L77/10
Abstract: A thermoset rubber composition includes a thermoset rubber having crystallized domains dispersed therein, the crystallized domains being formed of supramolecule building blocks forming a plurality of sheet-like structures through hydrogen bonding, the sheet-like structures interacting through non-covalent interactions to form the crystallized domains within the thermoset rubber. The supramolecular building blocks may be peptides, β-peptides, aramid oligomers, and bis-ureas.
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公开(公告)号：USD594781S1
公开(公告)日：2009-06-23
申请号：US29326987
申请日：2008-10-28
Applicant: ChuanFu Wang , YuBo Lian , Xin Tan
Designer： ChuanFu Wang , YuBo Lian , Xin Tan
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Patent Agency Ranking
公开(公告)号：USD592552S1
公开(公告)日：2009-05-19
申请号：US29325864
申请日：2008-10-07
Applicant: ChuanFu Wang , YuBo Lian , Jun Zhang , Xin Tan , Ka Dan
Designer： ChuanFu Wang , YuBo Lian , Jun Zhang , Xin Tan , Ka Dan
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