发明申请
- 专利标题： Modulation of HIF1alpha and HIF2alpha expression
- 专利标题（中）： HIF1alpha和HIF2alpha表达的调控
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申请号： US11527876申请日： 2006-09-26
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公开(公告)号： US20070020679A1公开(公告)日： 2007-01-25
- 发明人: Donna Ward , Kenneth Dobie , Eric Marcusson , Susan Freier
- 申请人： Donna Ward , Kenneth Dobie , Eric Marcusson , Susan Freier
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12Q1/68 ; C07H21/02 ; C07F9/6512
摘要：
Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
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