公开(公告)号：US20080027019A1

公开(公告)日：2008-01-31

申请号：US11748422

申请日：2007-05-14

申请人： Timothy Vickers ,  C. Bennett ,  Susan Freier ,  James Karras

发明人： Timothy Vickers ,  C. Bennett ,  Susan Freier ,  James Karras

IPC分类号： A61K31/7088 ,  A61K31/7115 ,  A61K31/7125 ,  A61P29/00

CPC分类号： A61K31/7088 ,  A61K31/7115 ,  A61K31/7125 ,  Y02P20/582

摘要： Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.

摘要翻译： 用与编码B7蛋白的核酸特异性杂交的寡核苷酸治疗哮喘的组合物和方法。

公开(公告)号：US20070238689A1

公开(公告)日：2007-10-11

申请号：US11697273

申请日：2007-04-05

申请人： Sanjay Bhanot ,  Susan Freier ,  Kenneth Dobie ,  Robert McKay

发明人： Sanjay Bhanot ,  Susan Freier ,  Kenneth Dobie ,  Robert McKay

IPC分类号： A61K31/711 ,  A61K31/7105 ,  A61K31/7125 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12N15/1138 ,  C07K14/705 ,  C07K14/723 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.

摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。

公开(公告)号：US20070238688A1

公开(公告)日：2007-10-11

申请号：US11697270

申请日：2007-04-05

申请人： Sanjay Bhanot ,  Susan Freier ,  Kenneth Dobie ,  Robert McKay

发明人： Sanjay Bhanot ,  Susan Freier ,  Kenneth Dobie ,  Robert McKay

IPC分类号： A61K31/711 ,  A61K31/7105 ,  A61K31/7125 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12N15/1138 ,  C07K14/705 ,  C07K14/723 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.

公开(公告)号：US20070021367A1

公开(公告)日：2007-01-25

申请号：US11505720

申请日：2006-08-17

申请人： Ian Popoff ,  Susan Freier ,  Kenneth Dobie

发明人： Ian Popoff ,  Susan Freier ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C07H21/04 ,  A61K38/00 ,  C12N15/1137 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of SOCS-3. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SOCS-3. Methods of using these compounds for modulation of SOCS-3 expression and for diagnosis and treatment of disease associated with expression of SOCS-3 are provided.

摘要翻译： 提供化合物，组合物和方法用于调节SOCS-3的表达。 组合物包含针对编码SOCS-3的核酸的寡核苷酸。 提供了使用这些化合物调节SOCS-3表达和用于诊断和治疗与SOCS-3表达相关的疾病的方法。

公开(公告)号：US20060074043A1

公开(公告)日：2006-04-06

申请号：US11250884

申请日：2005-10-13

申请人： Brett Monia ,  Susan Freier ,  Sanjay Bhanot ,  Madeline Butler ,  Andrew Watt ,  Jacqueline Wyatt ,  Brenda Baker ,  Lex Cowsert ,  Kenneth Dobie

发明人： Brett Monia ,  Susan Freier ,  Sanjay Bhanot ,  Madeline Butler ,  Andrew Watt ,  Jacqueline Wyatt ,  Brenda Baker ,  Lex Cowsert ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of matrix metalloproteinase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding matrix metalloproteinase 1. Methods of using these compounds for modulation of matrix metalloproteinase 1 expression and for treatment of diseases associated with expression of matrix metalloproteinase 1 are provided.

公开(公告)号：US20060025372A1

公开(公告)日：2006-02-02

申请号：US11194776

申请日：2005-08-01

申请人： Sanjay Bhanot ,  Lex Cowsert ,  Jacqueline Wyatt ,  Brett Monia ,  Madelline Butler ,  Robert McKay ,  Susan Freier ,  Kenneth Dobie

发明人： Sanjay Bhanot ,  Lex Cowsert ,  Jacqueline Wyatt ,  Brett Monia ,  Madelline Butler ,  Robert McKay ,  Susan Freier ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12Y301/03048 ,  Y02P20/582 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.

公开(公告)号：US20060019920A1

公开(公告)日：2006-01-26

申请号：US11179128

申请日：2005-07-11

申请人： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

发明人： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N9/1205 ,  Y02P20/582

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.

公开(公告)号：US20050215504A1

公开(公告)日：2005-09-29

申请号：US11014360

申请日：2004-12-16

申请人： C. Bennett ,  Susan Freier ,  Nicholas Dean ,  Brett Monia ,  William Gaarde ,  James Karras ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  Lex Cowsert ,  Erich Koller ,  Jacqueline Wyatt ,  Mark Roach ,  Andrew Watt ,  Brenda Baker ,  Kenneth Dobie

发明人： C. Bennett ,  Susan Freier ,  Nicholas Dean ,  Brett Monia ,  William Gaarde ,  James Karras ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  Lex Cowsert ,  Erich Koller ,  Jacqueline Wyatt ,  Mark Roach ,  Andrew Watt ,  Brenda Baker ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。

公开(公告)号：US20050203038A1

公开(公告)日：2005-09-15

申请号：US10798923

申请日：2004-03-10

申请人： Kenneth Dobie ,  Susan Freier

发明人： Kenneth Dobie ,  Susan Freier

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07H21/00 ,  A61K48/00

摘要： Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.

摘要翻译： 提供化合物，组合物和方法用于调节ACE2的表达。 组合物包含针对编码ACE2的核酸的寡核苷酸。 提供了使用这些化合物调节ACE2表达和诊断和治疗与ACE2表达相关的疾病和病症的方法。

公开(公告)号：US20050197309A1

公开(公告)日：2005-09-08

申请号：US11035809

申请日：2005-01-14

申请人： C. Bennett ,  Brett Monia ,  Susan Freier ,  Christopher Mirabelli ,  Ian Popoff ,  Jacqueline Wyatt ,  Andrew Watt ,  Kenneth Dobie

发明人： C. Bennett ,  Brett Monia ,  Susan Freier ,  Christopher Mirabelli ,  Ian Popoff ,  Jacqueline Wyatt ,  Andrew Watt ,  Kenneth Dobie

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12Y301/03016 ,  A61K38/00 ,  C07H21/04 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521 ,  C12Y301/03 ,  C12Y301/03048 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of dual specific phosphatase 5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding dual specific phosphatase 5. Methods of using these compounds for modulation of dual specific phosphatase 5 expression and for treatment of diseases associated with expression of dual specific phosphatase 5 are provided.