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公开(公告)号：US20070020679A1
公开(公告)日：2007-01-25
申请号：US11527876
申请日：2006-09-26
申请人： Donna Ward , Kenneth Dobie , Eric Marcusson , Susan Freier
发明人： Donna Ward , Kenneth Dobie , Eric Marcusson , Susan Freier
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02 , C07F9/6512
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
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公开(公告)号：US20060019920A1
公开(公告)日：2006-01-26
申请号：US11179128
申请日：2005-07-11
申请人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
发明人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
CPC分类号： C12N9/1205 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
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公开(公告)号：US20070066549A1
公开(公告)日：2007-03-22
申请号：US10571339
申请日：2004-09-17
申请人： Susan Freier , Kenneth Dobie , Eric Marcusson , Eric Swayze , Balkrishen Bhat , Jeremy Graff , Bruce Konicek
发明人： Susan Freier , Kenneth Dobie , Eric Marcusson , Eric Swayze , Balkrishen Bhat , Jeremy Graff , Bruce Konicek
IPC分类号： A61K48/00 , A61K38/16 , C07H21/02 , A61K31/704 , A61K31/522 , A61K31/403 , A61K31/4745 , A61K31/7072
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US20050153924A1
公开(公告)日：2005-07-14
申请号：US11013543
申请日：2004-12-15
申请人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
发明人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法 提供了与干扰素γ受体2表达相关的疾病的表达和治疗。
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公开(公告)号：US20050153925A1
公开(公告)日：2005-07-14
申请号：US11013608
申请日：2004-12-16
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of hepatocyte growth factor receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hepatocyte growth factor receptor. Methods of using these compounds for modulation of hepatocyte growth factor receptor expression and for diagnosis and treatment of disease associated with expression of hepatocyte growth factor receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节肝细胞生长因子受体的表达。 组合物包含针对编码肝细胞生长因子受体的核酸的寡核苷酸。 提供了使用这些化合物调节肝细胞生长因子受体表达和用于诊断和治疗与肝细胞生长因子受体表达相关的疾病的方法。
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公开(公告)号：US20050164254A1
公开(公告)日：2005-07-28
申请号：US11010227
申请日：2004-12-09
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/1138 , C12N2310/315 , C12N2310/322 , C12N2310/341 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of adipophilin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding adipophilin. Methods of using these compounds for modulation of adipophilin expression and for diagnosis and treatment of diseases and conditions associated with expression of adipophilin are provided.
摘要翻译： 提供化合物，组合物和方法用于调节adipophilin的表达。 组合物包含针对编码脂肪蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节脂肪蛋白表达和用于诊断和治疗与亲脂素表达相关的疾病和病症的方法。
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7.发明申请Compositions and their uses directed to cell growth and maintenance proteins 审中-公开组合物及其用于细胞生长和维持蛋白质的用途公开(公告)号：US20050186594A1
公开(公告)日：2005-08-25
申请号：US11015161
申请日：2004-12-17
申请人： C. Bennett , Susan Freier , Nicholas Dean , Ian Popoff , Brett Monia , Donna Ward , Ming-Yi Chiang , Ravi Jain , Kenneth Dobie
发明人： C. Bennett , Susan Freier , Nicholas Dean , Ian Popoff , Brett Monia , Donna Ward , Ming-Yi Chiang , Ravi Jain , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6811 , C12Q1/6883 , C12Q2600/158 , C12Q2600/16 , C12Y207/11001 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of G protein-coupled receptor kinase 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G protein-coupled receptor kinase 6. Methods of using these compounds for modulation of G protein-coupled receptor kinase 6 expression and for treatment of diseases associated with expression of G protein-coupled receptor kinase 6 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节G蛋白偶联受体激酶6的表达。组合物包含靶向编码G蛋白偶联受体激酶6的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物的方法 提供G蛋白偶联受体激酶6表达的调节和用于治疗与G蛋白偶联受体激酶6的表达相关的疾病。
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8.发明申请Antisense modulation of sterol regulatory element-binding protein-1 expression 审中-公开固醇调节元件结合蛋白-1表达的反义调制公开(公告)号：US20050215504A1
公开(公告)日：2005-09-29
申请号：US11014360
申请日：2004-12-16
申请人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
发明人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。
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公开(公告)号：US20050261228A1
公开(公告)日：2005-11-24
申请号：US11089191
申请日：2005-03-23
申请人： C. Bennett , Brenda Baker , Susan Freier , Susan Gregory , Ronnie Hanecak , Kevin Anderson , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt , Eric Marcusson , Nicholas Dean , Sanjay Bhanot , Elizabeth Ackermann , Lex Cowsert
发明人： C. Bennett , Brenda Baker , Susan Freier , Susan Gregory , Ronnie Hanecak , Kevin Anderson , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt , Eric Marcusson , Nicholas Dean , Sanjay Bhanot , Elizabeth Ackermann , Lex Cowsert
IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C12N15/113 , C12N15/85
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p35 subunit. The compositions comprise chemically modified antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p35 subunit. Methods of using these compounds for modulation of Interleukin 12 p35 subunit expression and for treatment of diseases associated with expression of Interleukin 12 p35 subunit are provided.
摘要翻译： 提供化合物，组合物和方法用于调节白细胞介素12p35亚基的表达。 组合物包含靶向编码白细胞介素12p35亚基的核酸的化学修饰的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节白介素12p35亚基表达和治疗与白细胞介素12p35亚基表达相关的疾病的方法。
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10.发明申请Oligomeric compounds and compositions for use in modulation small non-coding RNAs 失效用于调制小非编码RNA的低聚化合物和组合物公开(公告)号：US20050261218A1
公开(公告)日：2005-11-24
申请号：US10909125
申请日：2004-07-30
申请人： Christine Esau , Bridget Lollo , C. Bennett , Susan Freier , Richard Griffey , Brenda Baker , Timothy Vickers , Eric Marcusson , Erich Koller , Eric Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Bennett , Susan Freier , Richard Griffey , Brenda Baker , Timothy Vickers , Eric Marcusson , Erich Koller , Eric Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： A61K20060101 , A61K48/00 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。 组合物包含靶向小的非编码RNA的寡聚化合物。 还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。
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