- 专利标题: METHODS OF TREATING CANCER USING IL-21 AND MONOCLONAL ANTIBODY THERAPY
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申请号: US11539479申请日: 2006-10-06
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公开(公告)号: US20070048264A1公开(公告)日: 2007-03-01
- 发明人: Wayne Kindsvogel , Steven Hughes , Richard Holly , Christopher Clegg , Donald Foster , Rebecca Johnson , Mark Heipel , Pallavur Sivakumar
- 申请人: Wayne Kindsvogel , Steven Hughes , Richard Holly , Christopher Clegg , Donald Foster , Rebecca Johnson , Mark Heipel , Pallavur Sivakumar
- 专利权人: ZymoGenetics, Inc.
- 当前专利权人: ZymoGenetics, Inc.
- 主分类号: A61K38/20
- IPC分类号: A61K38/20 ; A61K39/395
摘要:
Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.