摘要:
The present invention relates to compounds of Formulas I and II, wherein A1, A2, B1, B2, Q, X1, X2, Y and R3 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.
摘要:
Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
摘要:
Various embodiments may provide an adjustable fit garment that allows the fit of the garment to be adjusted by a user according to the user's preferences. In various embodiments, the garment may be a jacket configured to be worn on an upper body of the user. The jacket may have an outer surface and an inner surface, and a front side and a back side. In various embodiments, one or more zippers may be disposed along the outside surface of the jacket. Each zipper may include two sets of opposing zipper teeth (e.g., first and second sets of zipper teeth) configured to be coupled together. The jacket may further include a gusset coupled between the sets of zipper teeth (e.g., on an interior portion of the zipper) to allow for a limited expansion of the jacket when the zipper is open.
摘要:
Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
摘要:
The invention discloses a synthesizing method of benzimidazole derivant and intermediate, which is characterized by the following: proceeding arylation among aryl halide and primary amine; adopting L-pro as additive, cuprous iodide as catalyst; proceeding molecular arylation coupling reaction for aryl iodide or aryl bromide and primary amine; adopting iodo phenylamine compound and bromophenylamine compound as starting material; synthesizing the material through several-step transformation.
摘要:
Systems and methods for generating a virtual reality training session for a procedure to be performed by at least one trainee on a virtual reality (VR) model of a physical object of interest in a technical environment. The method includes the steps of: loading the virtual reality (VR) model of the object of interest from a database into a virtual reality (VR) authoring system; specifying atomic procedural steps of the respective procedure by a technical expert and performing the specified atomic procedural steps in a virtual environment provided by the virtual reality (VR) authoring system by the technical expert on the loaded virtual reality (VR) model of the object of interest; and recording the atomic procedural steps performed by the technical expert in the virtual environment and linking the recorded atomic procedural steps to generate automatically the virtual reality training session stored in the database and available for the trainees.
摘要:
A system and method are provided for aligning a field of view (FOV) of a movable part of a medical device with a desired region on a subject's body. In the system, a position detecting unit detects an identifiable optical front projected on the subject's body and at least partially overlapping with the desired region and generates information corresponding to a spatial position of the identifiable optical front. From the information, a processing module determines the spatial position of the identifiable optical front with respect to a known position of the FOV and generates an instruction set that corresponds to one or more mechanical adjustments of the movable part to change a position of the FOV from the known position to the spatial position of the identifiable optical front. An executing module directs a moving mechanism of the movable part to carry out mechanical motions according to the instruction set.
摘要:
The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.