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公开(公告)号：US09449536B1
公开(公告)日：2016-09-20
申请号：US14697386
申请日：2015-04-27
Applicant: Sarah Marie Sanner , Emily Jean Hughes , Jeremy Ryan Sanner , Rodney Steven Hughes
Inventor： Sarah Marie Sanner , Emily Jean Hughes , Jeremy Ryan Sanner , Rodney Steven Hughes
CPC classification number: G09F7/18 , F16B2/22 , G09F2023/005
Abstract: A removable message board can include an attachment piece including a message displayed on a front side and a back side opposite the front side. A coiled spring can include a first end that directly contacts the back side of the attachment piece and a second end opposite the first end that is wound along a length of the coiled spring to form a concentric circular shape configured to press against a chair back. A top surface of the coiled spring can be oriented towards a bottom surface of the coiled spring. The coiled spring can be disposed behind the attachment piece such that the coiled spring can be substantially covered by the attachment piece when viewed from a position perpendicular to a length and width of the attachment piece.
Abstract translation: 可拆卸消息板可以包括附件，其包括显示在前侧和与前侧相对的后侧的消息。 螺旋弹簧可以包括直接接触安装件的后侧的第一端和与第一端相对的第二端，该第二端沿着螺旋弹簧的长度缠绕以形成被配置为压靠椅子背部的同心圆形。 螺旋弹簧的顶表面可以朝着螺旋弹簧的底表面定向。 螺旋弹簧可以设置在附接件的后面，使得当从垂直于附接件的长度和宽度的位置观察时，螺旋弹簧可以基本上被附接件覆盖。
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2.发明授权公开(公告)号：US09159872B2
公开(公告)日：2015-10-13
申请号：US13485756
申请日：2012-05-31
Applicant: Juanita Kurtin , Matthew J. Carillo , Steven Hughes
Inventor： Juanita Kurtin , Matthew J. Carillo , Steven Hughes
IPC: H01L29/06 , H01L33/04 , H01L21/02 , H01L33/50 , C09K11/02 , C09K11/56 , C09K11/88 , C01B19/00 , H01L33/06 , B82Y30/00 , H01L33/00 , B01J13/02 , B82Y40/00 , B82Y99/00
CPC classification number: H01L33/06 , B01J13/02 , B82Y30/00 , B82Y40/00 , B82Y99/00 , C01B19/007 , C01P2002/84 , C01P2004/04 , C01P2004/10 , C01P2004/54 , C01P2004/64 , C01P2004/80 , C09K11/02 , C09K11/025 , C09K11/565 , C09K11/883 , H01L21/02422 , H01L21/02557 , H01L21/0256 , H01L21/02601 , H01L21/02628 , H01L33/005 , H01L33/04 , H01L33/502
Abstract: Semiconductor structures having a nanocrystalline core and corresponding nanocrystalline shell are described. In an example, a semiconductor structure includes an anisotropic nanocrystalline core composed of a first semiconductor material and having an aspect ratio between, but not including, 1.0 and 2.0. The semiconductor structure also includes a nanocrystalline shell composed of a second, different, semiconductor material at least partially surrounding the anisotropic nanocrystalline core.
Abstract translation: 描述了具有纳米晶核和对应的纳米晶体壳的半导体结构。 在一个示例中，半导体结构包括由第一半导体材料构成并且具有但不包括1.0和2.0之间的纵横比的各向异性纳米晶核。 半导体结构还包括由至少部分地围绕各向异性纳米晶核的第二不同的半导体材料组成的纳米晶体壳。
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3.发明申请公开(公告)号：US20130112940A1
公开(公告)日：2013-05-09
申请号：US13485756
申请日：2012-05-31
Applicant: Juanita Kurtin , Matthew J. Carillo , Steven Hughes
Inventor： Juanita Kurtin , Matthew J. Carillo , Steven Hughes
CPC classification number: H01L33/06 , B01J13/02 , B82Y30/00 , B82Y40/00 , B82Y99/00 , C01B19/007 , C01P2002/84 , C01P2004/04 , C01P2004/10 , C01P2004/54 , C01P2004/64 , C01P2004/80 , C09K11/02 , C09K11/025 , C09K11/565 , C09K11/883 , H01L21/02422 , H01L21/02557 , H01L21/0256 , H01L21/02601 , H01L21/02628 , H01L33/005 , H01L33/04 , H01L33/502
Abstract: Semiconductor structures having a nanocrystalline core and corresponding nanocrystalline shell are described. In an example, a semiconductor structure includes an anisotropic nanocrystalline core composed of a first semiconductor material and having an aspect ratio between, but not including, 1.0 and 2.0. The semiconductor structure also includes a nanocrystalline shell composed of a second, different, semiconductor material at least partially surrounding the anisotropic nanocrystalline core.
Abstract translation: 描述了具有纳米晶核和对应的纳米晶体壳的半导体结构。 在一个示例中，半导体结构包括由第一半导体材料构成并且具有但不包括1.0和2.0之间的纵横比的各向异性纳米晶核。 半导体结构还包括由至少部分地围绕各向异性纳米晶核的第二不同的半导体材料组成的纳米晶体壳。
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公开(公告)号：US20080025946A1
公开(公告)日：2008-01-31
申请号：US11777852
申请日：2007-07-13
Applicant: Pallavur Sivakumar , Diana Hausman , Steven Hughes , Eric Sievers , Dennis Miller
Inventor： Pallavur Sivakumar , Diana Hausman , Steven Hughes , Eric Sievers , Dennis Miller
CPC classification number: A61K45/06 , A61K31/404 , A61K31/4412 , A61K38/20 , A61K2300/00
Abstract: The present invention provides methods for use of IL-21 in combination with a tyrosine kinase inhibitor (TKI) in treatment of diseases in which inhibition of phosphorylation via TK inhibition and modulation of immune function play a clinically beneficial role. These diseases include, but are not limited to, cancers, such as renal cell carcinoma and metastatic melanoma.
Abstract translation: 本发明提供了将IL-21与酪氨酸激酶抑制剂（TKI）组合用于治疗通过TK抑制和调节免疫功能的磷酸化抑制发挥临床有益作用的疾病的方法。 这些疾病包括但不限于癌症，例如肾细胞癌和转移性黑素瘤。
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公开(公告)号：US20070122382A1
公开(公告)日：2007-05-31
申请号：US11539493
申请日：2006-10-06
Applicant: Wayne Kindsvogel , Steven Hughes , Richard Holly , Christopher Clegg , Donald Foster , Rebecca Johnson , Mark Heipel , Pallavur Sivakumar
Inventor： Wayne Kindsvogel , Steven Hughes , Richard Holly , Christopher Clegg , Donald Foster , Rebecca Johnson , Mark Heipel , Pallavur Sivakumar
IPC: A61K39/395 , A61K38/20
CPC classification number: C07K16/32 , A61K38/20 , A61K39/395 , A61K39/39558 , C07K16/2818 , C07K16/2896 , C07K2317/732 , A61K2300/00
Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
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Patent Agency Ranking
公开(公告)号：US20070049549A1
公开(公告)日：2007-03-01
申请号：US11548554
申请日：2006-10-11
Applicant: Andrew Nelson , Steven Hughes , Richard Holly
Inventor： Andrew Nelson , Steven Hughes , Richard Holly
CPC classification number: C07K14/54 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2026 , A61K38/2086 , A61K45/06 , C07K16/2878 , C07K2317/73 , Y02A50/463 , Y02A50/465 , Y02A50/475 , Y02A50/481
Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
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公开(公告)号：US20070049548A1
公开(公告)日：2007-03-01
申请号：US11548538
申请日：2006-10-11
Applicant: Andrew Nelson , Steven Hughes , Richard Holly
Inventor： Andrew Nelson , Steven Hughes , Richard Holly
CPC classification number: C07K14/54 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2026 , A61K38/2086 , A61K45/06 , C07K16/2878 , C07K2317/73 , Y02A50/463 , Y02A50/465 , Y02A50/475 , Y02A50/481
Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
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公开(公告)号：US20070048272A1
公开(公告)日：2007-03-01
申请号：US11548963
申请日：2006-10-12
Applicant: Andrew Nelson , Steven Hughes , Richard Holly
Inventor： Andrew Nelson , Steven Hughes , Richard Holly
CPC classification number: C07K14/54 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2026 , A61K38/2086 , A61K45/06 , C07K16/2878 , C07K2317/73 , Y02A50/463 , Y02A50/465 , Y02A50/475 , Y02A50/481
Abstract: Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.
Abstract translation: 描述了使用具有IL-21功能活性的分子治疗具有癌症的哺乳动物的方法。 具有IL-21功能活性的分子包括与人IL-21多肽序列具有同源性的多肽和与具有IL-21功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其他已知的癌症治疗剂组合使用。
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公开(公告)号：US20070048264A1
公开(公告)日：2007-03-01
申请号：US11539479
申请日：2006-10-06
Applicant: Wayne Kindsvogel , Steven Hughes , Richard Holly , Christopher Clegg , Donald Foster , Rebecca Johnson , Mark Heipel , Pallavur Sivakumar
Inventor： Wayne Kindsvogel , Steven Hughes , Richard Holly , Christopher Clegg , Donald Foster , Rebecca Johnson , Mark Heipel , Pallavur Sivakumar
IPC: A61K38/20 , A61K39/395
CPC classification number: C07K16/32 , A61K38/20 , A61K39/395 , A61K39/39558 , C07K16/2818 , C07K16/2896 , C07K2317/732 , A61K2300/00
Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
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公开(公告)号：US20050065321A1
公开(公告)日：2005-03-24
申请号：US10968432
申请日：2004-10-19
Applicant: Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven Hughes
Inventor： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven Hughes
IPC: G01N33/53 , A61K38/00 , A61K39/395 , A61P1/04 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P39/02 , C07K14/715 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/574
CPC classification number: C07K14/715 , A61K38/00
Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
Abstract translation: 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor16”的新的人细胞因子受体。
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