发明申请
- 专利标题： Biological bypass bridge with sodium channels, calcium channels and/or potassium channels to compensate for conduction block in the heart
- 专利标题（中）： 具有钠通道，钙通道和/或钾通道的生物旁路桥以补偿心脏中的传导阻滞
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申请号： US11490760申请日： 2006-07-21
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公开(公告)号： US20070053886A1公开(公告)日： 2007-03-08
- 发明人: Michael Rosen , Peter Brink , Ira Cohen , Richard Robinson , Peter Danilo
- 申请人： Michael Rosen , Peter Brink , Ira Cohen , Richard Robinson , Peter Danilo
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; C12N5/08 ; A61K9/70
摘要：
This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.