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1.发明申请Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division 审中-公开使用人类干细胞和/或其产生的因子通过心肌细胞分裂促进成年哺乳动物心脏修复公开(公告)号：US20060234375A1
公开(公告)日：2006-10-19
申请号：US11240948
申请日：2005-09-29
申请人： Sergey Doronin , Ira Cohen , Peter Brink , Glenn Gaudette , Michael Rosen , Richard Robinson
发明人： Sergey Doronin , Ira Cohen , Peter Brink , Glenn Gaudette , Michael Rosen , Richard Robinson
CPC分类号： C12N5/0663 , A61K35/28 , A61K35/44 , A61K35/545
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject. Methods for determining whether an agent stimulates or inhibits myocyte proliferation.
摘要翻译： 一种用于在体内治疗患有心脏病症的受试者的方法，包括（i）在体外产生包含从细胞培养物调节的培养基的溶液，和（ii）向受试者施用步骤（i）的溶液， 从而治疗受试者的心脏病。 确定药物是否刺激或抑制肌细胞增殖的方法。
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公开(公告)号：US20060198829A1
公开(公告)日：2006-09-07
申请号：US11227533
申请日：2005-09-14
申请人： Michael Rosen , Richard Robinson , Ira Cohen , Peter Brink , Glenn Gaudette , Irina Potapova
发明人： Michael Rosen , Richard Robinson , Ira Cohen , Peter Brink , Glenn Gaudette , Irina Potapova
CPC分类号： C12N5/0657
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.
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公开(公告)号：US5270111A
公开(公告)日：1993-12-14
申请号：US966905
申请日：1992-10-27
CPC分类号： C09J7/0217 , A61L15/585 , A61L15/62 , Y10T428/2857
摘要： A method of using a pressure sensitive adhesive to form a moisture resistant, water-dispersible tape is provided. The adhesive and tape are resistant to autoclavation conditions and/or moisture and body fluids during usage, and are water-dispersible when immersed in aqueous solutions. The tape may be used with cloth body coverings, such as garments such as hospital gowns, drapes, dressings, diapers and other body coverings which require cloth to cloth or cloth to skin adhesion in the presence of moisture and bodily fluids yet be dispersible from such body coverings during laundering or other aqueous alkali immersion.
摘要翻译： 提供了使用压敏粘合剂形成防潮水分散性胶带的方法。 粘合剂和胶带在使用期间耐高压灭菌条件和/或湿气和体液，并且当浸入水溶液时是水分散的。 胶带可以与布身体覆盖物一起使用，例如衣服，例如医院长袍，窗帘，敷料，尿布和其他身体覆盖物，其需要布料或布料在水分和体液存在下的皮肤粘附，但是可以从其分散 洗衣期间的身体覆盖物或其他含水碱浸渍。
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4.发明授权Method of using a water-dispersible pressure sensitive adhesive tape on cloth body coverings 失效使用水分散压敏粘合胶带在衣服身上的方法
公开(公告)号：US5125995A
公开(公告)日：1992-06-30
申请号：US580116
申请日：1990-09-10
IPC分类号： A61L15/58 , A61L15/62 , C09J7/02 , C09J133/08
CPC分类号： C09J7/0217 , A61L15/585 , A61L15/62 , Y10T428/2891
摘要： A method of using a pressure sensitive adhesive to form a moisture resistant, water-dispersible tape is provided. The adhesive and tape are resistant to autoclavation conditions and/or moisture and body fluids during usage, and are water-dispersible when immersed in aqueous solutions. The tape may be used with cloth body coverings, such as garments such as hospital gowns, drapes, dressings, diapers and other body coverings which require cloth to cloth or cloth to skin adhesion in the presence of moisture and bodily fluids yet be dispersible from such body coverings during laundering or other aqueous alkali immersion.
摘要翻译： 提供了使用压敏粘合剂形成防潮水分散性胶带的方法。 粘合剂和胶带在使用期间耐高压灭菌条件和/或湿气和体液，并且当浸入水溶液时是水分散的。 胶带可以与布身体覆盖物一起使用，例如衣服，例如医院长袍，窗帘，敷料，尿布和其他身体覆盖物，其需要布料或布料在水分和体液存在下的皮肤粘附，但是可以从其分散 洗衣期间的身体覆盖物或其他含水碱浸渍。
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5.发明申请Compensating for Atrioventricular Block Using a Nucleic Acid Encoding a Sodium Channel or Gap Junction Protein 审中-公开使用编码钠通道或间隙结蛋白的核酸补偿房室传导阻滞公开(公告)号：US20110256112A2
公开(公告)日：2011-10-20
申请号：US12921395
申请日：2009-03-06
申请人： Ira Cohen , Peter Brink , Michael Rosen , Richard Robinson
发明人： Ira Cohen , Peter Brink , Michael Rosen , Richard Robinson
CPC分类号： A61K48/005 , A61K48/0075 , C07K14/705 , C12N2799/022 , C12N2799/04
摘要： A method of increasing the velocity of AV conduction in a mammal that may be in heart block or at risk of heart block by causing, in an AV node and/or His bundle having less than normal conduction speed, the expression of a sodium channel or gap junction protein, such as the SkM-1 channel, Cx43 or Cx32, so as to increase the velocity of conduction by the AV node.
摘要翻译： 通过在具有小于正常传导速度的AV结和/或His束中引起钠通道的表达或增加心脏阻塞或心脏阻塞风险的哺乳动物的AV传导速度的方法， 间隙连接蛋白，如SkM-1通道，Cx43或Cx32，以增加AV节点的传导速度。
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6.发明申请Delivery of Dna or Rna Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRna 有权通过从宿主细胞到靶细胞的间隙连接递送Dna或Rna以及用于反义或siRna的基于细胞的递送系统公开(公告)号：US20070224176A1
公开(公告)日：2007-09-27
申请号：US10583369
申请日：2004-12-17
申请人： Peter Brink , Michael Rosen , Richard Robinson , Ira Cohen , Arthur Grollman
发明人： Peter Brink , Michael Rosen , Richard Robinson , Ira Cohen , Arthur Grollman
IPC分类号： C12N15/00
CPC分类号： A61K48/0083 , C12N15/87
摘要： A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
摘要翻译： 将寡核苷酸或表达寡核苷酸的质粒递送到靶细胞的方法包括将寡核苷酸引入供体细胞，特别是干细胞，并在允许供体细胞形成间隙连接的条件下使靶细胞与供体细胞接触 与靶细胞接触，由此寡核苷酸或寡核苷酸的产物从供体细胞输送到靶细胞中。
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公开(公告)号：US20070113018A1
公开(公告)日：2007-05-17
申请号：US11273809
申请日：2005-11-14
申请人： Peter Brink , Shrikant Shah , Peter Munguia
发明人： Peter Brink , Shrikant Shah , Peter Munguia
IPC分类号： G06F12/00
CPC分类号： G06F12/0862
摘要： A discussion of a local memory with at least a command block section and a cache section that facilitates an efficient interrupt processing. The command-block section is allocated on a per interrupt basis and contains pointers to cache-lines. When an interrupt is recognized an interrupt, the proposal uses the pointers in the command-block to prefetch the corresponding cache-lines from the cache section of the local memory, which it loads into its local cache buffer. Thus, when the CPU recognizes an interrupt, the information for the context-switch is already available in cache.
摘要翻译： 对至少具有命令块部分和缓存部分的本地存储器的讨论有助于有效的中断处理。 命令块部分以每个中断为基础分配，并包含指向高速缓存行的指针。 当中断被识别为中断时，提案使用命令块中的指针从本地存储器的高速缓存部分预取相应的高速缓存行，并将其加载到其本地缓存缓冲区中。 因此，当CPU识别到中断时，上下文切换的信息已经在高速缓存中可用。
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8.发明申请Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division 审中-公开使用人类干细胞和/或其产生的因子通过心肌细胞分裂促进成年哺乳动物心脏修复公开(公告)号：US20070072294A1
公开(公告)日：2007-03-29
申请号：US11296018
申请日：2005-12-06
申请人： Sergey Doronin , Glenn Gaudette , Richard Robinson , Michael Rosen , Ira Cohen , Peter Brink
发明人： Sergey Doronin , Glenn Gaudette , Richard Robinson , Michael Rosen , Ira Cohen , Peter Brink
CPC分类号： A61L27/367 , A61K35/28 , A61K35/44 , A61K35/545 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/3843 , A61L27/3873 , A61L2430/20 , C12N5/0657 , C12N2501/33 , C12N2501/415 , C12N2502/1358 , C12N2510/00 , C12N2533/32 , C12N2533/52 , G01N33/5061 , G01N33/5073
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject. Methods for determining whether an agent stimulates or inhibits myocyte proliferation.
摘要翻译： 一种用于在体内治疗患有心脏病症的受试者的方法，包括（i）在体外产生包含从细胞培养物调节的培养基的溶液，和（ii）向受试者施用步骤（i）的溶液， 从而治疗受试者的心脏病。 确定药物是否刺激或抑制肌细胞增殖的方法。
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公开(公告)号：US20070005858A1
公开(公告)日：2007-01-04
申请号：US11171862
申请日：2005-06-30
申请人： Shrikant Shah , Peter Brink , Peter Munguia
发明人： Shrikant Shah , Peter Brink , Peter Munguia
IPC分类号： G06F12/14
CPC分类号： G06F13/24
摘要： Methods and arrangements to extend message signal interrupt (MSI) transactions with additional data to reduce the latency associated with servicing interrupts included in the transactions are contemplated. Some embodiments may comprise a chipset that transmits the MSI to a processor to service the interrupt. The chipset may identify that a transaction is an extended MSI transaction by determining that the MSI has more than a four bytes. In several embodiments, the chipset may validate the MSI by determining that the MSI comprises at least six bytes and, in further embodiments, by determining that the extended MSI has a valid signature byte. Another embodiment comprises a processor to receive the extended MSI transaction and store the data to service the corresponding interrupt(s) in a low latency buffer. The processor may then service the interrupt(s) based upon the data when the processor becomes available.
摘要翻译： 预期用于扩展具有附加数据的消息信号中断（MSI）事务以减少与事务中包括的服务中断相关联的延迟的方法和布置。 一些实施例可以包括将MSI发送到处理器来服务于中断的芯片组。 芯片组可以通过确定MSI具有多于四个字节来识别事务是扩展的MSI事务。 在几个实施例中，芯片组可以通过确定MSI包括至少六个字节并且在另外的实施例中通过确定扩展MSI具有有效的签名字节来验证MSI。 另一个实施例包括处理器，用于接收扩展的MSI事务并存储数据以服务于低延迟缓冲器中的相应中断。 然后，当处理器变得可用时，处理器可以基于数据来服务中断。
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10.发明申请Delivery of DNA or RNA Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRNA 有权通过从宿主细胞到靶细胞的间隙连接递送DNA或RNA，以及用于反义或siRNA的基于细胞的递送系统公开(公告)号：US20110275156A2
公开(公告)日：2011-11-10
申请号：US12910346
申请日：2010-10-22
申请人： Peter Brink , Michael Rosen , Richard Robinson , Ira Cohen , Arthur Grollman
发明人： Peter Brink , Michael Rosen , Richard Robinson , Ira Cohen , Arthur Grollman
CPC分类号： A61K48/0083 , C12N15/87
摘要： A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
摘要翻译： 将寡核苷酸或表达寡核苷酸的质粒递送到靶细胞的方法包括将寡核苷酸引入供体细胞，特别是干细胞，并在允许供体细胞形成间隙连接的条件下使靶细胞与供体细胞接触 与靶细胞接触，由此寡核苷酸或寡核苷酸的产物从供体细胞输送到靶细胞中。
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