Invention Application
US20070072858A1 Process for the stereoselective preparation of (-)-halofenate and derivatives thereof
失效
（ - ） - 卤代苯甲酸酯及其衍生物的立体选择性制备方法
- Patent Title: Process for the stereoselective preparation of (-)-halofenate and derivatives thereof
- Patent Title (中): （ - ） - 卤代苯甲酸酯及其衍生物的立体选择性制备方法
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Application No.: US11525200Application Date: 2006-09-20
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Publication No.: US20070072858A1Publication Date: 2007-03-29
- Inventor: Yan Zhu , Peng Cheng , Xin Chen , Jingyuan Ma , Zuchun Zhao
- Applicant: Yan Zhu , Peng Cheng , Xin Chen , Jingyuan Ma , Zuchun Zhao
- Applicant Address: US CA Hayward 94545
- Assignee: Metabolex, Inc.
- Current Assignee: Metabolex, Inc.
- Current Assignee Address: US CA Hayward 94545
- Main IPC: A61K31/5375
- IPC: A61K31/5375 ; A61K31/495 ; A61K31/4025 ; A61K31/401
Abstract:
The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1-C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4)aminoalkyl, amido, (C1-C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds
Public/Granted literature
- US07714131B2 Process for the stereoselective preparation of (−)-halofenate and derivatives thereof Public/Granted day:2010-05-11
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