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    Process for the stereoselective preparation of (-)-halofenate and derivatives thereof
    4.
    发明申请
    Process for the stereoselective preparation of (-)-halofenate and derivatives thereof 失效
    （ - ） - 卤代苯甲酸酯及其衍生物的立体选择性制备方法

    公开(公告)号：US20070072858A1

    公开(公告)日：2007-03-29

    申请号：US11525200

    申请日：2006-09-20

    申请人： Yan Zhu ,  Peng Cheng ,  Xin Chen ,  Jingyuan Ma ,  Zuchun Zhao

    发明人： Yan Zhu ,  Peng Cheng ,  Xin Chen ,  Jingyuan Ma ,  Zuchun Zhao

    IPC分类号： A61K31/5375 ,  A61K31/495 ,  A61K31/4025 ,  A61K31/401

    CPC分类号： C07D295/185

    摘要： The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1-C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4)aminoalkyl, amido, (C1-C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds

    摘要翻译： 本发明提供式（IV）化合物及其制备下式的α-（苯氧基）苯乙酸化合物的方法：其中R 1是选自以下的成员：各 R 2是独立地选自（C 1 -C 4 -C 4）烷基，卤素，（C 1 -C 4）烷基的成员， C 1 -C 4卤代烷基，氨基，（C 1 -C 4）氨基烷基，酰氨基，（C 1 H 4） （C 1 -C 4）磺酰基烷基，（C 1 -C 4）磺酰基烷基，（C 1 -C 4 - C 1 -C 4亚磺酰基烷基，（C 1 -C 4 -C 4）烷氧基，（C 1 -C 3 - 亚磺酰基烷基） > 4个）杂烷基，羧基和硝基; 当R 1具有式（a）或（b）时，下标n为1，当R 1具有式（c）或（d））时，下标n为1。 下标m为0〜3的整数; *表示富含一种立体异构构型的碳; 波浪线表示R 1的连接点; 和化合物