At least one aspect is directed to a totally artificial heart, and at least another aspect is directed to a method of controlling blood flow in a patient. The totally artificial heart may include a first rotary pump having an input to receive blood and an output to provide blood to a patient's lungs, a second rotary pump having an input to receive blood and an output to provide blood to the patient's body, a first sensor associated with the first rotary pump, a second sensor associated with the second rotary pump, and a control system coupled to the first sensor, the second sensor, the first rotary pump and the second rotary pump and configured to control characteristics of the first rotary pump and the second rotary pump based on signals received from at least one of the first sensor and the second sensor such that an average flow of blood through the second rotary pump is greater than an average flow of blood through the first rotary pump