发明申请
US20070082936A1 Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives
失效
芳基异恶唑-4-羰基 - 吲哚羧酸酰胺衍生物
- 专利标题： Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives
- 专利标题（中）： 芳基异恶唑-4-羰基 - 吲哚羧酸酰胺衍生物
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申请号： US11543178申请日： 2006-10-04
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公开(公告)号： US20070082936A1公开(公告)日： 2007-04-12
- 发明人: Bernd Buettelmann , Bo Han , Henner Knust , Matthias Nettekoven , Andrew Thomas
- 申请人： Bernd Buettelmann , Bo Han , Henner Knust , Matthias Nettekoven , Andrew Thomas
- 优先权： EP05109424.1 20051011
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; C07D413/02
摘要：
The present invention is concerned with aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives of formula I wherein R1, R2, R3, R4, and R5 are as defined in the specification and claims and with their pharmaceutically acceptable acid addition salts. The invention also relates to methods for preparing such compounds. This class of compounds has a high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease. Thus, the invention also is concerned with pharmaceutical compositions containing compounds of formula I or their pharmaceutically acceptable acid addition salts and methods for the treatment of GABA A α5 mediated diseases, including Alzheimer's disease.
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