发明申请
- 专利标题: Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
- 专利标题(中): 具有长羟基化链的生育酚衍生物,可用作神经营养
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申请号: US10572933申请日: 2004-09-24
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公开(公告)号: US20070105946A1公开(公告)日: 2007-05-10
- 发明人: Bang Luu , Paul Heuschling , Thierry Muller , Eleonora Morga
- 申请人: Bang Luu , Paul Heuschling , Thierry Muller , Eleonora Morga
- 申请人地址: FR Strasbourg F-67000 FR Paris Cedex F-75794 LU Luxembourg-Limpertsberg L-1511
- 专利权人: UNIVERSITE LOUIS PASTEUR,CENTRAL NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE DU LUXEMBOURG
- 当前专利权人: UNIVERSITE LOUIS PASTEUR,CENTRAL NATIONAL DE LA RECHERCHE SCIENTIFIQUE,UNIVERSITE DU LUXEMBOURG
- 当前专利权人地址: FR Strasbourg F-67000 FR Paris Cedex F-75794 LU Luxembourg-Limpertsberg L-1511
- 优先权: FR0311325 20030926
- 国际申请: PCT/FR04/02424 WO 20040924
- 主分类号: A61K31/353
- IPC分类号: A61K31/353 ; A61K31/343
摘要:
The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.
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