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    NUCLEAR FUEL ROD SPACER GRID AND FRAMEWORK AND ASSEMBLY COMPRISING SUCH A GRID
    1.
    发明申请
    NUCLEAR FUEL ROD SPACER GRID AND FRAMEWORK AND ASSEMBLY COMPRISING SUCH A GRID 有权
    核燃料空间网格和框架以及包含这种网格的装配

    公开(公告)号：US20100246747A1

    公开(公告)日：2010-09-30

    申请号：US12741572

    申请日：2008-10-30

    申请人： Noemie Gomez ,  Angelo Beati ,  Dominique Hertz ,  Thierry Muller

    发明人： Noemie Gomez ,  Angelo Beati ,  Dominique Hertz ,  Thierry Muller

    IPC分类号： G21C3/34

    CPC分类号： G21C3/34 ,  G21C3/334 ,  G21Y2002/302 ,  G21Y2004/30 ,  Y02E30/40

    摘要： A grid including at least two meshed grid parts intended to be superposed in a longitudinal direction, each grid part extending in a transverse plane, and the grid parts being moveable one relative to the other in at least one transverse direction between an open configuration for the insertion of nuclear fuel rods in the longitudinal direction through the grid parts, and a closed configuration allowing each fuel rod inserted through the grid parts to be clamped transversely between the grid parts. According to one aspect of the invention, the grid includes elements for transversely immobilizing the grid parts in the closed configuration, the immobilizing elements being designed to engage as the superposed grid parts are moved closer together in the longitudinal direction.

    摘要翻译： 包括至少两个网格部分的网格，所述网格部分旨在在纵向方向上重叠，每个网格部分在横向平面中延伸，并且网格部分可以在至少一个横向方向上相对于另一个相对移动， 核燃料棒沿纵向方向插入格栅部分，并且封闭构造允许插入通过格栅部分的每个燃料棒横向地夹在网格部分之间。 根据本发明的一个方面，所述网格包括用于将栅格部分横向固定在封闭构造中的元件，所述固定元件设计成当所述叠置的栅格部分在纵向方向上更靠近地移动时被接合。

    Method of producing nanoparticle suspensions
    3.
    发明授权
    Method of producing nanoparticle suspensions 有权
    制备纳米颗粒悬浮液的方法

    公开(公告)号：US09296685B2

    公开(公告)日：2016-03-29

    申请号：US13583536

    申请日：2011-03-07

    申请人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

    发明人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

    IPC分类号： C07C69/36 ,  C07C271/08 ,  B01F17/00 ,  C07C69/38 ,  C07C233/56

    CPC分类号： C07C271/08 ,  B01F17/0007 ,  B01F17/0021 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56

    摘要： Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.

    摘要翻译： 制备纳米颗粒悬浮液的方法，步骤（i）制备分散极性相的乳液，其中水相包含一种或多种形成纳米颗粒的前体物质，在连续的有机相中，在稳定乳液的乳化剂存在下 ，（ii）将一种或多种前体物质转化为分散水相中的纳米颗粒，（iii）破乳和相分离，其中纳米颗粒悬浮液作为一相获得，（iv）将纳米颗粒悬浮液分离 ，（v）任选地从纳米颗粒悬浮液中分离纳米颗粒，其中所述乳化剂选自X为O，NH，Y为C（O），NH，R为饱和的或通式 具有6至30个碳原子的单或多不饱和的直链或支链烃基，R 1是氢或C 1 -C 4 - 烷基，R 2是饱和或单不饱和或多不饱和的直链或支链烃 具有1至30个碳原子，优选6至30个碳原子的二烷基，R 3是C 1 -C 4 - 烷基，n是0或1，并且通过分裂乳化剂来实现乳液的断裂。

    METHOD OF PRODUCING NANOPARTICLE SUSPENSIONS
    4.
    发明申请
    METHOD OF PRODUCING NANOPARTICLE SUSPENSIONS 有权
    制备纳米悬浮液的方法

    公开(公告)号：US20120329888A1

    公开(公告)日：2012-12-27

    申请号：US13583536

    申请日：2011-03-07

    申请人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

    发明人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

    IPC分类号： B01J13/00 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56 ,  C07C271/12

    CPC分类号： C07C271/08 ,  B01F17/0007 ,  B01F17/0021 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56

    摘要： Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.

    摘要翻译： 制备纳米颗粒悬浮液的方法，步骤（i）制备分散极性相的乳液，其中水相包含一种或多种形成纳米颗粒的前体物质，在连续的有机相中，在稳定乳液的乳化剂存在下 ，（ii）将一种或多种前体物质转化为分散水相中的纳米颗粒，（iii）破乳和相分离，其中纳米颗粒悬浮液作为一相获得，（iv）将纳米颗粒悬浮液分离 ，（v）任选地从纳米颗粒悬浮液中分离纳米颗粒，其中所述乳化剂选自X为O，NH，Y为C（O），NH，R为饱和的或通式 具有6至30个碳原子的单或多不饱和的直链或支链烃基，R 1是氢或C 1 -C 4 - 烷基，R 2是饱和或单不饱和或多不饱和的直链或支链烃 具有1至30个碳原子，优选6至30个碳原子的二烷基，R 3是C 1 -C 4 - 烷基，n是0或1，并且通过分裂乳化剂来实现乳液的断裂。

    Pressurised water nuclear reactor vessel
    5.
    发明授权
    Pressurised water nuclear reactor vessel 有权
    加压水核反应堆

    公开(公告)号：US07929657B2

    公开(公告)日：2011-04-19

    申请号：US11591575

    申请日：2006-11-02

    申请人： Thierry Muller ,  Philippe Dolleans ,  Fabien Hensch

    发明人： Thierry Muller ,  Philippe Dolleans ,  Fabien Hensch

    IPC分类号： G21C15/00 ,  G21C15/24

    CPC分类号： G21C13/02 ,  G21C5/10 ,  G21Y2002/201 ,  G21Y2004/302 ,  Y02E30/40

    摘要： The invention relates to a pressurised water nuclear reactor vessel, comprising: an outer casing which comprises at least one cylindrical shell and a dished bottom head, a core support plate, a vessel bottom head space being delimited between the support plate and the dished bottom head, the support plate being perforated with holes for circulation of the primary coolant which place the vessel bottom head space in communication with the core, a calming device which is arranged in the vessel bottom head space, wherein the calming device comprises at least one calming plate which is substantially perpendicular relative to the centre axis of the vessel and a plurality of calming holes, the calming holes being provided in the calming plate and being capable of calming the primary coolant by passing the fluid through the holes.

    摘要翻译： 本发明涉及一种加压水核反应堆容器，包括：外壳，其包括至少一个圆柱形外壳和一个凹陷底部头部，一个芯部支撑板，容器底部顶部空间限定在该支撑板和该底部底部头部之间 所述支撑板上穿有孔，用于使所述主要冷却剂循环，所述孔将所述容器底部顶部空间与所述芯体连通，所述平坦装置布置在所述容器底部顶部空间中，其中所述镇定装置包括至少一个镇定板 其基本上相对于容器的中心轴线垂直并具有多个平静孔，平静孔设置在镇静板中，并且能够使流体通过孔而使主冷却剂平静。

    Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
    6.
    发明授权
    Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics 失效
    具有长羟基化链的生育酚衍生物，可用作神经营养

    公开(公告)号：US07691900B2

    公开(公告)日：2010-04-06

    申请号：US10572933

    申请日：2004-09-24

    申请人： Bang Luu ,  Paul Heuschling ,  Thierry Muller ,  Eleonora Morga

    发明人： Bang Luu ,  Paul Heuschling ,  Thierry Muller ,  Eleonora Morga

    IPC分类号： A01N43/02 ,  A01N43/16 ,  A61K31/335 ,  A61K31/35

    CPC分类号： C07D311/72 ,  C07D307/80

    摘要： The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.

    摘要翻译： 本发明涉及任何分离或合成的化合物，特别是具有式的化合物，其可以：调节神经干细胞的细胞规格，促进分化的神经胶质细胞和神经元的分化和随后的存活，并促进少突胶质细胞前体的分化 细胞进入成熟的少突胶质细胞。 此外，本发明化合物可以减少影响神经系统的疾病的炎症成分，例如通过减少小胶质细胞和/或星形胶质细胞的活化和/或通过减少反应性胶质增生。 本发明还涉及制备这些化合物的方法及其在制备用于预防或治疗影响神经系统的疾病的药物组合物中的用途。 更具体地，本发明化合物具有通式。

    Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
    7.
    发明申请
    Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics 失效
    具有长羟基化链的生育酚衍生物，可用作神经营养

    公开(公告)号：US20070105946A1

    公开(公告)日：2007-05-10

    申请号：US10572933

    申请日：2004-09-24

    申请人： Bang Luu ,  Paul Heuschling ,  Thierry Muller ,  Eleonora Morga

    发明人： Bang Luu ,  Paul Heuschling ,  Thierry Muller ,  Eleonora Morga

    IPC分类号： A61K31/353 ,  A61K31/343

    CPC分类号： C07D311/72 ,  C07D307/80

    摘要： The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.

    摘要翻译： 本发明涉及任何分离或合成的化合物，特别是具有式的化合物，其可以：调节神经干细胞的细胞规格，促进分化的神经胶质细胞和神经元的分化和随后的存活，并促进少突胶质细胞前体的分化 细胞进入成熟的少突胶质细胞。 此外，本发明化合物可以减少影响神经系统的疾病的炎症成分，例如通过减少小胶质细胞和/或星形胶质细胞的活化和/或通过减少反应性胶质增生。 本发明还涉及制备这些化合物的方法及其在制备用于预防或治疗影响神经系统的疾病的药物组合物中的用途。 更具体地，本发明化合物具有通式。

    Nuclear reactor primary circuit
    8.
    发明授权
    Nuclear reactor primary circuit 失效
    核反应堆初级电路

    公开(公告)号：US08660229B2

    公开(公告)日：2014-02-25

    申请号：US12094000

    申请日：2006-11-14

    申请人： Guy Barois ,  Jean-Georges Alibaud ,  Thierry Muller ,  Christelle Dumez

    发明人： Guy Barois ,  Jean-Georges Alibaud ,  Thierry Muller ,  Christelle Dumez

    IPC分类号： G21C7/32

    CPC分类号： B01F3/0865 ,  B01F5/045 ,  G21C13/032 ,  G21C15/22 ,  G21D1/02 ,  G21Y2002/303 ,  G21Y2004/302 ,  Y02E30/40

    摘要： The invention relates to a nuclear reactor primary circuit comprising a primary pipeline (30), which defines an internal volume (32) and in which a primary nuclear reactor coolant downwardly runs, an additional pipeline (26) which is branched to the primary pipeline (30) and defines an internal volume communicating with the internal volume (32) of the primary pipeline (30) and a cuff (36) whose first end (50) is connected to the additional pipeline (26) and the second free end (52) is positioned in the internal volume (32) of the primary pipeline (30). According to said invention, the second end (52) is delimited by a free peripherial edge (53) comprising at least one upstream and downstream sections (56, 58) which are oriented towards the upstream, wherein the upstream section (56) penetrates into the internal volume (32) deeper from the primary pipeline (30) than the downstream section (58).

    摘要翻译： 本发明涉及一种核反应堆初级回路，其包括限定内部容积（32）的初级管线（30），其中初级核反应堆冷却剂向下运行，附加管道（26）被分支到主管道 30）并且限定与主管道（30）的内​​部容积（32）连通的内部容积和其第一端（50）连接到附加管道（26）和第二自由端（52）的袖带（36） ）位于主管线（30）的内​​部容积（32）中。 根据所述发明，第二端（52）由包括至少一个朝向上游方向定向的上游和下游部分（56,58）的自由周缘（53）界定，其中上游部分（56）穿入 所述内部容积（32）从所述主管道（30）比所述下游部分（58）更深。

    NUCLEAR REACTOR PRIMARY CIRCUIT
    9.
    发明申请
    NUCLEAR REACTOR PRIMARY CIRCUIT 失效
    核反应堆主电路

    公开(公告)号：US20090141848A1

    公开(公告)日：2009-06-04

    申请号：US12094000

    申请日：2006-11-14

    申请人： Guy Barois ,  Jean-Georges Alibaud ,  Thierry Muller ,  Christelle Dumez

    发明人： Guy Barois ,  Jean-Georges Alibaud ,  Thierry Muller ,  Christelle Dumez

    IPC分类号： G21C7/32

    CPC分类号： B01F3/0865 ,  B01F5/045 ,  G21C13/032 ,  G21C15/22 ,  G21D1/02 ,  G21Y2002/303 ,  G21Y2004/302 ,  Y02E30/40

    摘要： The invention relates to a nuclear reactor primary circuit comprising a primary pipeline (30), which defines an internal volume (32) and in which a primary nuclear reactor coolant downwardly runs, an additional pipeline (26) which is branched to the primary pipeline (30) and defines an internal volume communicating with the internal volume (32) of the primary pipeline (30) and a cuff (36) whose first end (50) is connected to the additional pipeline (26) and the second free end (52) is positioned in the internal volume (32) of the primary pipeline (30). According to said invention, the second end (52) is delimited by a free peripherial edge (53) comprising at least one upstream and downstream sections (56, 58) which are oriented towards the upstream, wherein the upstream section (56) penetrates into the internal volume (32) deeper from the primary pipeline (30) than the downstream section (58).

    摘要翻译： 本发明涉及一种核反应堆初级回路，其包括限定内部容积（32）的初级管线（30），其中初级核反应堆冷却剂向下运行，附加管道（26）被分支到主管道 30）并且限定与主管道（30）的内​​部容积（32）连通的内部容积和其第一端（50）连接到附加管道（26）和第二自由端（52）的袖带（36） ）位于主管线（30）的内​​部容积（32）中。 根据所述发明，第二端（52）由包括至少一个朝向上游方向定向的上游和下游部分（56,58）的自由周缘（53）界定，其中上游部分（56）穿入 所述内部容积（32）从所述主管道（30）比所述下游部分（58）更深。