公开(公告)号：US07691900B2

公开(公告)日：2010-04-06

申请号：US10572933

申请日：2004-09-24

申请人： Bang Luu ,  Paul Heuschling ,  Thierry Muller ,  Eleonora Morga

发明人： Bang Luu ,  Paul Heuschling ,  Thierry Muller ,  Eleonora Morga

IPC分类号： A01N43/02 ,  A01N43/16 ,  A61K31/335 ,  A61K31/35

CPC分类号： C07D311/72 ,  C07D307/80

摘要： The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.

摘要翻译： 本发明涉及任何分离或合成的化合物，特别是具有式的化合物，其可以：调节神经干细胞的细胞规格，促进分化的神经胶质细胞和神经元的分化和随后的存活，并促进少突胶质细胞前体的分化 细胞进入成熟的少突胶质细胞。 此外，本发明化合物可以减少影响神经系统的疾病的炎症成分，例如通过减少小胶质细胞和/或星形胶质细胞的活化和/或通过减少反应性胶质增生。 本发明还涉及制备这些化合物的方法及其在制备用于预防或治疗影响神经系统的疾病的药物组合物中的用途。 更具体地，本发明化合物具有通式。

公开(公告)号：US20070105946A1

公开(公告)日：2007-05-10

申请号：US10572933

申请日：2004-09-24

申请人： Bang Luu ,  Paul Heuschling ,  Thierry Muller ,  Eleonora Morga

发明人： Bang Luu ,  Paul Heuschling ,  Thierry Muller ,  Eleonora Morga

IPC分类号： A61K31/353 ,  A61K31/343

CPC分类号： C07D311/72 ,  C07D307/80

摘要： The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.

摘要翻译： 本发明涉及任何分离或合成的化合物，特别是具有式的化合物，其可以：调节神经干细胞的细胞规格，促进分化的神经胶质细胞和神经元的分化和随后的存活，并促进少突胶质细胞前体的分化 细胞进入成熟的少突胶质细胞。 此外，本发明化合物可以减少影响神经系统的疾病的炎症成分，例如通过减少小胶质细胞和/或星形胶质细胞的活化和/或通过减少反应性胶质增生。 本发明还涉及制备这些化合物的方法及其在制备用于预防或治疗影响神经系统的疾病的药物组合物中的用途。 更具体地，本发明化合物具有通式。

公开(公告)号：US20100048731A1

公开(公告)日：2010-02-25

申请号：US12224692

申请日：2007-03-02

申请人： Bang Luu ,  Frédérique Hauss ,  Djalil Coowar ,  Jiawei Liu ,  Paul Heuschling ,  Eleonora Morga ,  Luc Grandbarbe ,  Alessandro Michelucci

发明人： Bang Luu ,  Frédérique Hauss ,  Djalil Coowar ,  Jiawei Liu ,  Paul Heuschling ,  Eleonora Morga ,  Luc Grandbarbe ,  Alessandro Michelucci

IPC分类号： A61K31/085 ,  C07C39/12 ,  C07C43/20 ,  A61K31/05 ,  A61P25/00

CPC分类号： C07C39/21 ,  C07C43/23

摘要： The present invention relates to a compound of general formula (I) below in which R1, R2 and R3 represent, independently of one another, a hydrogen atom or a C1-C6 alkyl group or a (C1-C6 alkyl)carbonyl group, R4, R5, R6 and R7 represent a hydrogen or a C1-C6 alkyl group, a C1-C6 alkoxy group or a (C1-C6 alkyl)carbonyloxy group, and n is an integer between 8 and 20, or its pharmaceutically acceptable addition salts, isomers, enantiomers and diastereoisomers, and also mixtures thereof. The invention also relates to a pharmaceutical composition comprising the compound and to the use thereof as a neurotrophic agent.

摘要翻译： 本发明涉及以下通式（I）的化合物，其中R 1，R 2和R 3彼此独立地表示氢原子或C 1 -C 6烷基或（C 1 -C 6烷基）羰基，R 4 ，R5，R6和R7表示氢或C1-C6烷基，C1-C6烷氧基或（C1-C6烷基）羰氧基，n为8至20的整数，或其药学上可接受的加成盐 异构体，对映异构体和非对映异构体，以及它们的混合物。 本发明还涉及包含该化合物的药物组合物及其作为神经营养剂的用途。