An endoscope enclosure for sterilizing an endoscope having a body, and a first flexible tube attached to the body. The endoscope enclosure has an interior space for receiving the endoscope in an orientation with the first flexible tube depending vertically downwardly from the endoscope body. It includes both an inlet fluid connector and an outlet fluid connector, each fluidly communicating with the interior space and which has an closure for isolating the interior space from an exterior environment therethrough. The interior space is sealed from the exterior environment so that an endoscope can be sterilized by passing fluid through the interior space via the inlet and outlet fluid connectors and stored therein in an orientation with the first flexible tube depending downwardly, and in sterile form being protected from ingress of potentially contaminating microorganisms.