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    CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME
    4.
    发明申请
    CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME 审中-公开
    CONCATAMERIC LIGATION产品：组合物方法和用途相同

    公开(公告)号：US20120190019A1

    公开(公告)日：2012-07-26

    申请号：US13333302

    申请日：2011-12-21

    申请人： Caifu Chen ,  Kevin Hennessy ,  Kai Qin Lao ,  Teodoro Paner ,  Vinod Mirchandani

    发明人： Caifu Chen ,  Kevin Hennessy ,  Kai Qin Lao ,  Teodoro Paner ,  Vinod Mirchandani

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6876 ,  C12Q1/6816 ,  C12Q2533/107 ,  C12Q2525/301

    摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.

    摘要翻译： 本教导涉及用于检测样品中的一种或多种靶多核苷酸序列的方法，组合物和试剂盒，以及用于形成连续连接产物的方法组合物和试剂盒。 在本教导的一些实施方案中，寡核苷酸与互补靶多核苷酸杂交并连接在一起以形成连接产物。 在本教导的一些实施方案中，可以扩增连续连接产物，并且基于在连接反应中引入的序列确定靶多核苷酸的身份和数量。 本教导的一些实施方案提供从反应混合物中除去未螯合的探针的方法。 本教导的一些实施方案使用各种分析程序提供多重检测，鉴定和定量多个靶多核苷酸。

    CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME
    5.
    发明申请
    CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME 审中-公开
    CONCATAMERIC LIGATION产品：组合物方法和用途相同

    公开(公告)号：US20100015631A1

    公开(公告)日：2010-01-21

    申请号：US12559476

    申请日：2009-09-14

    申请人： Caifu CHEN ,  Kevin Hennessy ,  Kai Qin Lao ,  Teodoro Paner ,  Vinod Mirchandani

    发明人： Caifu CHEN ,  Kevin Hennessy ,  Kai Qin Lao ,  Teodoro Paner ,  Vinod Mirchandani

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6876 ,  C12Q1/6816 ,  C12Q2533/107 ,  C12Q2525/301

    摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures.

    摘要翻译： 本教导涉及用于检测样品中的一种或多种靶多核苷酸序列的方法，组合物和试剂盒，以及用于形成连续连接产物的方法组合物和试剂盒。 在本教导的一些实施方案中，寡核苷酸与互补靶多核苷酸杂交并连接在一起以形成连接产物。 在本教导的一些实施方案中，可以扩增连续连接产物，并且基于在连接反应中引入的序列确定靶多核苷酸的身份和数量。 本教导的一些实施方案提供从反应混合物中除去未螯合的探针的方法。 本教导的一些实施方案使用各种分析程序提供多重检测，鉴定和定量多个靶多核苷酸。

    Temperature control for light-emitting diode stabilization
    6.
    发明申请
    Temperature control for light-emitting diode stabilization 审中-公开
    温度控制用于发光二极管稳定

    公开(公告)号：US20050279949A1

    公开(公告)日：2005-12-22

    申请号：US10981440

    申请日：2004-11-04

    申请人： Mark Oldham ,  Vinod Mirchandani

    发明人： Mark Oldham ,  Vinod Mirchandani

    IPC分类号： F21V9/16 ,  G01N21/01 ,  G01N21/64

    CPC分类号： G01N21/64 ,  F21K9/00 ,  F21K9/64 ,  F21V29/54 ,  F21V29/677 ,  F21V29/74 ,  F21Y2115/10 ,  G01J3/0286 ,  G01J3/10 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0638 ,  G01N2201/1211 ,  G05D23/1919 ,  G05D23/20

    摘要： A system is provided that includes a light-emitting diode (LED); a temperature sensor in thermal contact with the LED and capable of measuring an operating temperature and generating an operating temperature signal; and a temperature regulating system capable of receiving the operating temperature signal and regulating the operating temperature based on the operating temperature signal. A method for stabilizing the temperature of an LED is provided. A method is provided that includes providing a system comprising an LED, a reaction region, and a sample in the reaction region; generating excitation beams with the LED; directing excitation beams to the sample; detecting an optical property of the sample to obtain detection data; measuring the operating temperature of the light emitting diode; and adjusting the detection data of an excitation beam characteristic shift related to the operating temperature, when the LED is operated at the operating temperature to generate the excitation beams.

    摘要翻译： 提供一种包括发光二极管（LED）的系统; 与LED热接触的温度传感器，能够测量工作温度并产生工作温度信号; 以及能够基于工作温度信号接收工作温度信号和调节工作温度的温度调节系统。 提供了一种用于稳定LED的温度的方法。 提供了一种方法，其包括在反应区域中提供包括LED，反应区域和样品的系统; 用LED产生激励光束; 将激发光束引导到样品; 检测样品的光学特性以获得检测数据; 测量发光二极管的工作温度; 并且当LED在操作温度下操作以产生激发光束时，调整与工作温度相关的激发光束特性偏移的检测数据。

    Accurate laser power control for dual/multiple beams
    7.
    发明授权
    Accurate laser power control for dual/multiple beams 失效
    双/多光束的精确激光功率控制

    公开(公告)号：US5671078A

    公开(公告)日：1997-09-23

    申请号：US673883

    申请日：1996-07-01

    申请人： Vinod Mirchandani

    发明人： Vinod Mirchandani

    IPC分类号： G02B26/12 ,  G02B26/08

    CPC分类号： G02B26/127 ,  Y10S359/90

    摘要： There is disclosed a method of reducing banding problem in multi-diode raster scanning systems. In this invention a test mode is provided for measuring and adjusting the output power of the laser diodes. During the test mode an individual patch is used for the light beam of each diode to individually measure and adjust the output power of each laser diode. By individually adjusting the output power of each laser diode to a required level, the banding problem is substantially reduced.

    摘要翻译： 公开了一种在多二极管光栅扫描系统中减少带状问题的方法。 在本发明中，提供测试和调节激光二极管的输出功率的测试模式。 在测试模式期间，每个二极管的光束使用单个贴片来单独测量和调整每个激光二极管的输出功率。 通过将每个激光二极管的输出功率单独调整到所需的水平，带状问题显着降低。

    Optimal filling of a polygon facet by beam reprofiling
    9.
    发明授权
    Optimal filling of a polygon facet by beam reprofiling 失效
    通过光束重新填充多边形面的最佳填充

    公开(公告)号：US5367400A

    公开(公告)日：1994-11-22

    申请号：US990492

    申请日：1992-12-14

    申请人： Ellis D. Harris ,  Vinod Mirchandani

    发明人： Ellis D. Harris ,  Vinod Mirchandani

    IPC分类号： G02B26/12 ,  G02B27/00 ,  G02B26/08

    CPC分类号： G02B27/4227 ,  G02B27/0037 ,  G02B27/4277

    摘要： A raster scanner system is disclosed which utilizes a pair of binary diffraction optic lenses to correct non-uniformity of the flux of a light beam received by a facet of a rotating polygon. Since the facet is rotating and the direction of the light is constant, the amount of the light (flux) which the facet receives in each position from the start of scan to the end of scan and in any position therebetween is different. Also, the light beam striking the rotating facet has a Gaussian distribution which is a contributor to the non-uniformity of the flux over one scan line. The binary diffraction optic lenses of this invention reprofiles the Gaussian distribution into a profile in which the intensity of the light beam gradually increases as the facet rotates to provide a uniform flux for the entire scan line.

    摘要翻译： 公开了一种光栅扫描器系统，其利用一对二进制衍射光学透镜来校正由旋转多边形的面接收的光束的通量的不均匀性。 由于小面旋转并且光的方向是恒定的，所以小面在从扫描开始到扫描结束的每个位置以及它们之间的任何位置中接收的光量（通量）是不同的。 此外，撞击旋转小面的光束具有高斯分布，其是对一条扫描线上的通量的不均匀性的贡献者。 本发明的二进制衍射光学透镜将高斯分布重新构造成轮廓，其中光束的强度随着小面旋转而逐渐增加，以为整个扫描线提供均匀的通量。

    APPARATUS AND METHOD FOR PROVIDING FLOW TO ENDOSCOPE CHANNELS
    10.
    发明申请
    APPARATUS AND METHOD FOR PROVIDING FLOW TO ENDOSCOPE CHANNELS 审中-公开
    用于向内窥镜通道提供流量的装置和方法

    公开(公告)号：US20110169260A1

    公开(公告)日：2011-07-14

    申请号：US13034804

    申请日：2011-02-25

    申请人： Szu-Min Lin ,  Robert C. Platt, JR. ,  Vinod Mirchandani

    发明人： Szu-Min Lin ,  Robert C. Platt, JR. ,  Vinod Mirchandani

    IPC分类号： F16L39/00

    CPC分类号： A61B1/123 ,  A61B1/00068 ,  A61B1/125 ,  A61B90/70 ,  A61B2090/701

    摘要： A method provides flow to multiple channels in an endoscope during an endoscope decontamination procedure. A member is inserted into a chamber in a body of an endoscope through an opening into the chamber, the chamber being intersected by a first lumen and a second lumen. The member separates fluidly the first lumen from the second lumen. Fluid is flowed through a first channel through the member into the first lumen and through a second channel through the member into the second lumen. Additional lumens can be so treated at the same time. Fluids can include detergents and other cleaning fluids, disinfectants and sterilants.

    摘要翻译： 在内窥镜去污过程中，一种方法提供流入内窥镜中的多个通道。 一个构件通过开口进入腔内插入到内窥镜体内的腔室中，腔室被第一腔和第二腔相交。 该构件将第一腔与第二腔流体分开。 流体通过第一通道穿过构件流入第一管腔并通过穿过构件的第二通道进入第二管腔。 额外的流明可以同时进行治疗。 流体可以包括洗涤剂和其它清洁液，消毒剂和灭菌剂。