发明申请
US20070160604A1 METHODS OF IDENTIFYING COMPOUNDS CAPABLE OF MODULATING T CELL IMMUNE RESPONSES INVOLVING SEMA4A PROTEIN
审中-公开
鉴定涉及SEMA4A蛋白的调节T细胞免疫应答的化合物的方法
- 专利标题： METHODS OF IDENTIFYING COMPOUNDS CAPABLE OF MODULATING T CELL IMMUNE RESPONSES INVOLVING SEMA4A PROTEIN
- 专利标题（中）： 鉴定涉及SEMA4A蛋白的调节T细胞免疫应答的化合物的方法
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申请号： US11668121申请日： 2007-01-29
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公开(公告)号： US20070160604A1公开(公告)日： 2007-07-12
- 发明人: Hitoshi Kikutani , Atsushi Kumanogoh , Edward Barsoumian
- 申请人： Hitoshi Kikutani , Atsushi Kumanogoh , Edward Barsoumian
- 优先权： DE10213762.5 20020326
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/567
摘要：
The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.
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